Document Detail

Non-pharmacological aspects of blood pressure management: what are the data?
MedLine Citation:
PMID:  21389976     Owner:  NLM     Status:  MEDLINE    
Hypertension affects 29% of US adults and is a significant risk factor for cardiovascular morbidity and mortality. Epidemiological data support contribution of several dietary and other lifestyle-related factors to the development of high blood pressure (BP). Several clinical trials investigated the efficacy of non-pharmacological interventions and lifestyle modifications to reduce BP. Best evidence from randomized controlled trials supports BP-lowering effects of weight loss, the Dietary Approaches to Stop Hypertension (DASH) diet, and dietary sodium (Na(+)) reduction in those with prehypertension, with more pronounced effects in those with hypertension. In hypertensive participants, the effects on BP of DASH combined with low Na(+) alone or with the addition of weight loss were greater than or equal to those of single-drug therapy. Trials where food was provided to participants were more successful in showing a BP-lowering effect. However, clinical studies with long-term follow-up revealed that lifestyle modifications were difficult to maintain. Findings from controlled trials of increased potassium, calcium, or magnesium intake, or reduction in alcohol intake revealed modest BP-lowering effects and are less conclusive. The reported effects of exercise independent of weight loss on BP are inconsistent.
S Susan Hedayati; Essam F Elsayed; Robert F Reilly
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-03-09
Journal Detail:
Title:  Kidney international     Volume:  79     ISSN:  1523-1755     ISO Abbreviation:  Kidney Int.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-29     Completed Date:  2011-08-24     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1061-70     Citation Subset:  IM    
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MeSH Terms
Alcohol Drinking
Calcium, Dietary / administration & dosage
Clinical Trials as Topic
Diet, Sodium-Restricted
Hypertension / therapy*
Magnesium / administration & dosage
Potassium, Dietary / administration & dosage
Weight Loss
Grant Support
Reg. No./Substance:
0/Calcium, Dietary; 0/Potassium, Dietary; I38ZP9992A/Magnesium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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