| Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy. | |
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MedLine Citation:
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PMID: 18767026 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A critical regulator of the apoptotic machinery is the Bcl-2 family proteins whose over expression confers a protective effect on malignant cells against death signals of apoptosis. Cancer cells that are resistant to various anti-cancer drugs and treatment regimen are found to over express these Bcl-2 proteins such as Bcl-2, Bcl-X(L), Mcl-1, Bcl-w, and A1/Bfl1. In recent years there has been an exponential growth in the identification as well as synthesis of non-peptidic cell permeable small-molecule inhibitors (SMIs) of protein-protein interaction. The focus of this article is on inhibitors of anti-apoptotic protein Bcl-2. This review summarizes an up to date knowledge of the available SMIs, their mode of action as well as their current status in preclinical as well as clinical development. |
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Authors:
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Asfar S Azmi; Ramzi M Mohammad |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of cellular physiology Volume: 218 ISSN: 1097-4652 ISO Abbreviation: J. Cell. Physiol. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-11-03 Completed Date: 2008-12-09 Revised Date: 2011-05-16 |
Medline Journal Info:
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Nlm Unique ID: 0050222 Medline TA: J Cell Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 13-21 Citation Subset: IM |
Copyright Information:
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(c) 2008 Wiley-Liss, Inc. |
Affiliation:
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Department of Pathology, Wayne State University School of Medicine, Detroit Michigan, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aniline Compounds
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pharmacology Animals Apoptosis / drug effects, physiology Benzamides / pharmacology Binding Sites Biphenyl Compounds / pharmacology Gossypol / analogs & derivatives, pharmacology Humans Lymphoma / drug therapy Models, Molecular Neoplasms / drug therapy*, pathology, physiopathology Nitrophenols / pharmacology Piperazines / pharmacology Protein Structure, Tertiary Proto-Oncogene Proteins c-bcl-2 / antagonists & inhibitors*, chemistry, classification, physiology Pyrroles / pharmacology Sulfonamides / pharmacology Sulfones / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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CA109389/CA/NCI NIH HHS; R01 CA 109389/CA/NCI NIH HHS; R01 CA109389-01A2/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/ABT 263; 0/ABT-737; 0/Aniline Compounds; 0/Benzamides; 0/Biphenyl Compounds; 0/Nitrophenols; 0/Piperazines; 0/Proto-Oncogene Proteins c-bcl-2; 0/Pyrroles; 0/Sulfonamides; 0/Sulfones; 0/TW-37 compound; 0/obatoclax; 303-45-7/Gossypol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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