Document Detail


Non-pathogenic bacterial flora may inhibit colonization by methicillin-resistant Staphylococcus aureus in extremely low birth weight infants.
MedLine Citation:
PMID:  17878742     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To evaluate our hypothesis that non-pathogenic bacterial flora inhibit later colonization with methicillin-resistant Staphylococcus aureus (MRSA) in extremely low birth weight (ELBW) infants, we performed a retrospective investigation of the association between non-pathogenic bacterial flora and later inhibition of colonization by MRSA in ELBW infants. METHODS: A total of 110 preterm infants with birth weight <1,000 g admitted to the Neonatal Intensive Care Unit of Nagano Children's Hospital from January 1997 to December 2003 were analyzed retrospectively with regard to colonization by MRSA during hospitalization. We investigated the incidence of MRSA colonization in 56 infants with non-pathogenic bacterial flora in the oral cavity during the first week after birth and compared them with 54 infants lacking non-pathogenic bacteria. RESULTS: Incidence rate of colonization by MRSA at postnatal week 6 was significantly lower in infants with non-pathogenic bacterial flora in the oral cavity (32.1%) than in infants without such bacteria during the first week of life (77.8%; p < 0.001). CONCLUSIONS: The present results suggest an important role for non-pathogenic bacterial flora in the oral cavity during early life in prevention of later MRSA colonization in ELBW infants.
Authors:
Akiko Shimizu; Kenji Shimizu; Tomohiko Nakamura
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-09-18
Journal Detail:
Title:  Neonatology     Volume:  93     ISSN:  1661-7819     ISO Abbreviation:  -     Publication Date:  2008  
Date Detail:
Created Date:  2008-03-27     Completed Date:  2008-05-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101286577     Medline TA:  Neonatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  158-61     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2007 S. Karger AG, Basel.
Affiliation:
Division of Neonatology, Nagano Children's Hospital, Azumino City, Japan.
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MeSH Terms
Descriptor/Qualifier:
Humans
Incidence
Infant, Extremely Low Birth Weight
Infant, Newborn
Methicillin Resistance
Mouth / microbiology*
Retrospective Studies
Staphylococcal Infections / epidemiology,  microbiology*,  prevention & control
Staphylococcus aureus / growth & development*

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