Document Detail


Non-noradrenergic sympathetic neurons project to extramuscular feed arteries and proximal intramuscular arteries of skeletal muscles in guinea-pig hindlimbs.
MedLine Citation:
PMID:  8912254     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study set out to examine the non-noradrenergic sympathetic innervation of extramuscular and intramuscular arterial vessels supplying hindlimb muscles of guinea-pigs, using multiple-labelling fluorescence immunohistochemistry. Non-noradrenergic axons, identified by their immunoreactivity (IR) to vasoactive intestinal peptide (VIP) and neuropeptide Y (NPY), innervated nearly all (> or = 88%) extramuscular feed arteries supplying muscles of the medial thigh. The distribution of non-noradrenergic axons along extramuscular feed arteries was often patchy, with increased density near some branch points. The density of axons with VIP-IR and NPY-IR at the adventitia-medial junction of the largest extramuscular arteries was similar to the density of noradrenergic axons identified by IR to tyrosine hydroxylase (TH) and NPY. The proportion of arterial vessels innervated by VIP-IR axons decreased in more distal, intramuscular arterial segments, and when present, the VIP-IR axons were fewer in number than TH-IR axons innervating the same segments. Distal arterioles (< 20 microns diameter) were never innervated by VIP-IR axons, but always by TH-Ir axons. The non-noradrenergic sympathetic neurons are almost certainly vasodilator neurons. The prominent innervation of extramuscular feed arteries by sympathetic non-noradrenergic neurons has not been reported previously, even in cats and dogs where there is good physiological evidence for a sympathetic vasodilator response in skeletal muscles. The present morphological results provide compelling reasons for re-evaluating the functional role of sympathetic vasodilation in skeletal muscles of rodents, particularly in relation to the role of feed arteries in neural regulation of muscle blood flow.
Authors:
R L Anderson; I L Gibbins; J L Morris
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the autonomic nervous system     Volume:  61     ISSN:  0165-1838     ISO Abbreviation:  J. Auton. Nerv. Syst.     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-03-04     Completed Date:  1997-03-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8003419     Medline TA:  J Auton Nerv Syst     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  51-60     Citation Subset:  IM    
Affiliation:
Department of Anatomy and Histology, School of Medicine, Flinders University of South Australia, Adelaide, Australia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arteries / anatomy & histology,  innervation*,  physiology
Arterioles / innervation,  physiology
Autonomic Pathways / anatomy & histology,  cytology,  physiology
Axons / physiology
Guinea Pigs
Hindlimb / anatomy & histology,  blood supply*,  innervation
Image Processing, Computer-Assisted
Immunohistochemistry
Muscle, Skeletal / anatomy & histology,  blood supply*,  innervation
Neurons / physiology*
Neuropeptide Y / metabolism
Norepinephrine / physiology
Sympathetic Nervous System / cytology,  physiology*
Tyrosine 3-Monooxygenase / metabolism
Vasoactive Intestinal Peptide / metabolism
Chemical
Reg. No./Substance:
0/Neuropeptide Y; 37221-79-7/Vasoactive Intestinal Peptide; 51-41-2/Norepinephrine; EC 1.14.16.2/Tyrosine 3-Monooxygenase
Comments/Corrections
Erratum In:
J Auton Nerv Syst 1997 Mar 19;63(1-2):101-5

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