Document Detail

Non-neurogenic sarcomas in four children and young adults with neurofibromatosis type 1.
MedLine Citation:
PMID:  15103715     Owner:  NLM     Status:  MEDLINE    
It is well known that children and young adults with neurofibromatosis type 1 (NF1) have a higher risk for non-neurogenic sarcomas than the general population, in addition to an increased risk for malignant peripheral nerve sheath tumor. When non-neurogenic sarcomas occur in early childhood, a subsequent malignant peripheral nerve sheath tumor can occur as a second malignant neoplasm, especially after alkylating agent chemotherapy and irradiation. This report includes the clinicopathologic features of non-neurogenic sarcomas and secondary malignant peripheral nerve sheath tumor in the context of four cases of NF1. The purpose is to emphasize that early diagnosis of NF1 and recognition of potential manifestations of non-neurogenic sarcomas are important for clinical care of these patients and their families.
Cheryl M Coffin; Jamie Cassity; David Viskochil; R Lor Randall; Karen Albritton
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of medical genetics. Part A     Volume:  127A     ISSN:  1552-4825     ISO Abbreviation:  Am. J. Med. Genet. A     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-22     Completed Date:  2004-11-09     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  101235741     Medline TA:  Am J Med Genet A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  40-3     Citation Subset:  IM    
Copyright Information:
Copyright 2004 Wiley-Liss, Inc.
Department of Pathology, The University of Utah School of Medicine, 100 North Medical Drive, Salt Lake City, UT 84113, USA.
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MeSH Terms
Child, Preschool
Neoplasms, Second Primary / diagnosis*,  genetics
Nerve Sheath Neoplasms / genetics,  secondary
Neurofibromatosis 1 / diagnosis*,  genetics
Phyllodes Tumor / diagnosis
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics
Rhabdomyosarcoma, Embryonal / diagnosis,  genetics
Sarcoma / diagnosis*,  genetics

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