| Non-natural nucleic acids for synthetic biology. | |
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MedLine Citation:
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PMID: 19879178 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Genetic manipulation is an important facet of synthetic biology but can be complicated by undesired nuclease degradation. Incorporating non-natural nucleic acids into a gene could convey resistance to nucleases and promote expression. The compatibility of non-natural nucleosides with polymerases is reviewed with a focus on results from the past two years. Details are provided about how the different systems could be useful in synthetic biology. |
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Authors:
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Daniel H Appella |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural; Review Date: 2009-10-29 |
Journal Detail:
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Title: Current opinion in chemical biology Volume: 13 ISSN: 1879-0402 ISO Abbreviation: Curr Opin Chem Biol Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-02 Completed Date: 2010-01-29 Revised Date: 2011-08-25 |
Medline Journal Info:
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Nlm Unique ID: 9811312 Medline TA: Curr Opin Chem Biol Country: England |
Other Details:
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Languages: eng Pagination: 687-96 Citation Subset: IM |
Affiliation:
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National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. appellad@niddk.nih.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aptamers, Nucleotide / genetics, metabolism Bioengineering / methods* Biology / methods* Furans / chemistry Humans Nucleic Acids / chemistry*, genetics, metabolism Phosphates / chemistry |
| Grant Support | |
ID/Acronym/Agency:
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ZIA DK031143-06/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Aptamers, Nucleotide; 0/Furans; 0/Nucleic Acids; 0/Phosphates; 110-00-9/furan |
| Comments/Corrections | |
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