| Non-metastatic osteosarcoma of the extremities in children aged 5 years or younger. | |
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MedLine Citation:
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PMID: 20806363 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The occurrence of high-grade osteosarcoma is rare in children aged 5 years or younger and only limited series or case reports have been described. METHODS: The records of patients aged 5 years or younger with non-metastatic high-grade osteosarcoma of the extremities treated with surgery and adjuvant or neo-adjuvant chemotherapy at Rizzoli Institute between 1972 and 1999 were retrospectively evaluated in relation to gender, primary tumor site, histological subtype, surgical treatment, chemotherapy-induced tumor necrosis, 5- and 10-year event-free survival (EFS), and rate of local recurrence. Data were compared to patients aged 6-40 years entered with the same diagnosis and over the same time interval. RESULTS: Data from 20 patients were collected. Comparing these data with those from 1,106 patients 6-40 years of age only two main differences resulted: the younger group showed a higher rate for fibroblastic subtype (P < 0.01) and for amputation surgery (P < 0.01). Among the two groups, no statistical difference was observed for the 5-year EFS (60% vs. 53.8%; P = 0.6) and 10-year EFS (60% vs. 52.1%; P = 0.5). The rate of local recurrence was 5.0% and 5.4%. CONCLUSIONS: These findings suggest that in non-metastatic osteosarcoma of the extremities outcome and clinical characteristics are similar among children 5 years of age or younger and older patients. However, in the younger group we have observed a significant higher rate of fibroblastic subtype as well as a significant higher rate of mutilating surgery. Pediatr Blood Cancer. |
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Authors:
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Massimo Eraldo Abate; Alessandra Longhi; Stefano Galletti; Stefano Ferrari; Gaetano Bacci |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric blood & cancer Volume: 55 ISSN: 1545-5017 ISO Abbreviation: Pediatr Blood Cancer Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-08-31 Completed Date: 2010-09-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101186624 Medline TA: Pediatr Blood Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 652-4 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Wiley-Liss, Inc. |
Affiliation:
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Department of Chemotherapy, Istituto Ortopedico Rizzoli, Bologna, Italy. massimo.abate@ior.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Bone Neoplasms / epidemiology*, therapy Child Child, Preschool Extremities Female Humans Infant Infant, Newborn Male Osteosarcoma / epidemiology*, therapy |
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