Document Detail

Non-marrow hematopoiesis occurs in a hyaluronic acid-rich node and duct system in mice.
MedLine Citation:
PMID:  24914588     Owner:  NLM     Status:  Publisher    
A hyaluronic acid-rich node and duct system (HAR-NDS) was found on the surface of internal organs of mice, and inside their blood and lymph vessels. The nodes (HAR-N) were filled with immune cells of the innate system and were especially enriched with mast cells and histiocytes. They also contained hematopoietic progenitor cells (HPCs) such as granulocyte-macrophage (CFU-GM), erythroid (BFU-E), multipotential (CFU-GEMM) progenitors and mast cell progenitors (MCPs). MCPs were the most abundant among the HPCs in HAR-N. Their frequency was five-fold higher than that of the MCPs in bone marrow. In addition, the system contained pluripotent stem cells (PSCs) capable of producing CD45<sup>-</sup>Flk1<sup>+</sup> hemangioblast-like cells, which subsequently generated various types of HPC and differentiated blood cells. Although HAR-N did not appear to harbor enough number of cells capable of long-term reconstitution or short-term radioprotection of lethally-irradiated recipients, bone marrow cells were able to engraft in the HAR-NDS and to reconstitute hematopoietic potentials of the system. PSC and HPC were consistently found in intravenous, intralymphatic, and intestinal hyaluronic acid-rich nodes and ducts (HAR-ND). We infer that PSC and HPC reside in the HAR-ND and that this novel system may serve as an alternative means to traffic immature and mature blood cells throughout the body.
Sunhee Hwang; Seung J Lee; Sang H Park; Brahmananda R Chitteti; Edward F Srour; Scott Cooper; Giao Hangoc; Hal E Broxmeyer; Byoung S Kwon
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-10
Journal Detail:
Title:  Stem cells and development     Volume:  -     ISSN:  1557-8534     ISO Abbreviation:  Stem Cells Dev.     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101197107     Medline TA:  Stem Cells Dev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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