Document Detail


Non-lethal infection of aminergic reticular core neurons: age-dependent spread of ts mutant vesicular stomatitis virus from the nose.
MedLine Citation:
PMID:  2845000     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to induce a non-lethal infection restricted to central aminergic neurons projecting to the olfactory bulbs a series of temperature sensitive (ts) and G-protein monoclonal antibody escape mutants of vesicular stomatitis virus (VSV) were instilled into the nasal cavity of mice. In three-week (wk)-old NMRI mice four monoclonal antibody escape mutants caused an extensive infection of the olfactory epithelium and, like a wild type strain, a lethal brain infection after spread along olfactory pathways. Three ts mutant strains showed an attenuated pathogenic potential. Strain G31 caused a lethal infection with a somewhat prolonged course while the strain G11 failed to invade the nervous system. Strain G41 showed minimal invasion of central nervous system in three-wk-old mice and caused a lethal infection in newborn and one-wk-old mice. In contrast, two-wk-old mice survived infection with this mutant, which spread along olfactory pathways and rather selectively affected aminergic reticular core neurons in the diagonal band, the locus ceruleus and the raphe nuclei in the brainstem. Thus, an age-dependent virus infection of the olfactory pathways can cause restricted lesions in the brain providing a model for studies of virus-induced changes in aminergic neurotransmission.
Authors:
B Lundh; A Löve; K Kristensson; E Norrby
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuropathology and experimental neurology     Volume:  47     ISSN:  0022-3069     ISO Abbreviation:  J. Neuropathol. Exp. Neurol.     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1988-11-01     Completed Date:  1988-11-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2985192R     Medline TA:  J Neuropathol Exp Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  497-506     Citation Subset:  IM    
Affiliation:
Department of Pathology (Division of Neuropathology), Karolinska Institute, Stockholm, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Aging
Animals
Antigens, Viral / analysis
Brain / growth & development,  microbiology*
Cell Line
DNA Replication
Epithelium / microbiology
Mice
Mice, Inbred BALB C
Mice, Inbred Strains
Mutation
Nasal Mucosa / microbiology*
Neurons / microbiology*
Olfactory Bulb / growth & development,  microbiology
Vesicular stomatitis Indiana virus / genetics,  growth & development,  pathogenicity*
Virus Replication
Chemical
Reg. No./Substance:
0/Antigens, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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