Document Detail


Non-ketotic hyperglycinaemia: clinical and biochemical aspects.
MedLine Citation:
PMID:  3297708     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Non-ketotic hyperglycinaemia is an autosomal recessive disorder of glycine metabolism characterized by elevated concentrations of glycine in plasma, urine and cerebrospinal fluid. The fundamental defect was found to lie in the glycine cleavage system. It is of significance that the major pathway for the catabolism of glycine was elucidated through the studies of hyperglycinaemia. The present knowledge about non-ketotic hyperglycinaemia is described in clinical and biochemical aspects.
Authors:
K Tada; K Hayasaka
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  European journal of pediatrics     Volume:  146     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-07-28     Completed Date:  1987-07-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  221-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Metabolism, Inborn Errors / genetics*,  metabolism
Amino Acid Oxidoreductases / metabolism*
Brain / metabolism
Carrier Proteins / metabolism*
Diagnosis, Differential
Electroencephalography
Genes, Recessive*
Glycine / metabolism*
Humans
Infant
Infant, Newborn
Ketosis / metabolism
Liver / metabolism
Multienzyme Complexes / metabolism*
Transferases / metabolism*
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Multienzyme Complexes; 0/glycine cleavage system; 56-40-6/Glycine; EC 1.4.-/Amino Acid Oxidoreductases; EC 2.-/Transferases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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