| Non-invasive vessel examinations in carriers of LDL-receptor defective gene versus non-carriers with newly detected asymptomatic severe hypercholesterolemia. | |
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MedLine Citation:
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PMID: 21462887 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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AIM: To investigate the difference between severe hypercholesterolemia patients that carry LDL-R defective gene and those that do not have it, in their functional (flow-mediated vasodilation) and structural (intima-media thickness of carotid artery and ankle-brachial index) characteristics of arterial wall. PATIENTS AND METHODS: The study included 120 hypercholesterolemic patients. Biochemistry parameters were studied by routine methods. The flow-mediated vasodilation (%FMD), ankle-brachial index (ABI) and intima-media thickness (IMT) of common carotid artery were determined using Hewlett Packard Sonos 5 500; MedicaSoft. IMT.lab was the software programme used in the study. RESULTS: There was no significant difference between the groups with respect to total cholesterol, LDL, HDL, Apo-B, Apo-A1, cellular adhesion molecules (sICAM-1, sVCAM-1, sP- and sE-selectine). The Apo-B/Apo A1 index differed significantly (t = 11.23, p < 0.001) between the two groups; there was difference even after adjustment for age. There was no significant difference in the endothelial dependent and independent vasodilatation between the examined groups (p > 0.05). We found a significantly greater carotid IMT and lower ABI in the carriers than the respective parameters in the non-carriers. This significant difference was confirmed after adjustment for age. CONCLUSION: Our data show that LDL-R carriers have a higher carotid IMT and lower ABI than non-carriers, whereas no difference between the groups was found with respect to the level of lipid parameters and %FMD. |
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Authors:
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Lyudmila G Vladimirova-Kitova; Tania I Deneva-Koicheva; Fedya P Nikolov; Varban S Ganev |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Folia medica Volume: 52 ISSN: 0204-8043 ISO Abbreviation: Folia Med (Plovdiv) Publication Date: 2010 Oct-Dec |
Date Detail:
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Created Date: 2011-04-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2984761R Medline TA: Folia Med (Plovdiv) Country: Bulgaria |
Other Details:
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Languages: eng Pagination: 13-22 Citation Subset: IM |
Affiliation:
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Clinic of Cardiology, Medical University, Plovdiv, Bulgaria. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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