Document Detail

Non-invasive ventilation for pulmonary edema associated with tocolytic agents during labour for a twin pregnancy
MedLine Citation:
PMID:  19138917     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To describe the efficacy and patient acceptance of non-invasive ventilation for pulmonary edema associated with administration of tocolytic drugs during labour of a twin pregnancy. CLINICAL FEATURES: We report the case of a 31-yr-old parturient at 34 weeks gestation of a twin pregnancy, who experienced acute pulmonary edema after tocolytic treatment with nifedipine, nicardipine and atosiban of > 48 hr in duration. This patient presented with hypoxia during labour and non-invasive ventilation was successfully used allowing delivery by vaginal approach, with patient-controlled epidural analgesia, of two twins with a five minute Apgar score of 8. Investigations showed acute pulmonary edema and important transudate pleural effusions with left ventricular systolic dysfunction induced by calcium-antagonist, with favourable outcome after symptomatic treatment. CONCLUSION: When pulmonary edema occurs during pregnancy, non-invasive ventilation could be an efficacious treatment, this avoiding tracheal intubation and its complications.
Sébastien Perbet; Jean-Michel Constantin; Franck Bolandard; Marie Vignaud; Denis Gallot; Sylvain Chanséaume; Marie Zénut; Jean-Etienne Bazin
Publication Detail:
Type:  Case Reports; English Abstract; Journal Article    
Journal Detail:
Title:  Canadian journal of anaesthesia = Journal canadien d'anesthésie     Volume:  55     ISSN:  0832-610X     ISO Abbreviation:  Can J Anaesth     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2009-01-13     Completed Date:  2009-02-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701709     Medline TA:  Can J Anaesth     Country:  Canada    
Other Details:
Languages:  fre     Pagination:  769-73     Citation Subset:  IM    
Département d'Anesthésie et de Réanimation, Hôtel-Dieu, Centre Hospitalier Universitaire de Clermont-Ferrand, Boulevard Léon-Malfreyt, 63058 Clermont-Ferrand Cedex 1, France.
Vernacular Title:
Ventilation non-invasive pour oedème pulmonaire attribué aux tocolytiques lors du travail d'une grossesse gémellaire.
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MeSH Terms
Apgar Score
Delivery, Obstetric*
Infant, Newborn
Nicardipine / adverse effects
Nifedipine / adverse effects
Pleural Effusion / drug therapy
Pulmonary Edema / chemically induced*,  therapy*
Respiration, Artificial*
Tocolytic Agents / adverse effects*
Tomography, X-Ray Computed
Vasotocin / adverse effects,  analogs & derivatives
Reg. No./Substance:
0/Tocolytic Agents; 21829-25-4/Nifedipine; 55985-32-5/Nicardipine; 9034-50-8/Vasotocin; 90779-69-4/atosiban

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