Document Detail

Non-invasive studies of peripheral vascular compliance using a non-occluding photoplethysmographic method.
MedLine Citation:
PMID:  10367467     Owner:  NLM     Status:  MEDLINE    
A non-invasive technique is implemented to measure a peripheral vascular compliance index Cindex, using an infrared photoplethysmographic waveform as an indicator of intravascular volume change and a continuous blood pressure monitor to measure the blood pressure during each heart-beat. The non-linear behaviour of Cindex with pressure and the effect of age on Cindex are studied in 62 males (15-73 years). Repeatability tests and the effect of ice-water exposure of a portion of a limb are studied in 10 and 14 subjects, respectively. For each individual, Cindex measurements are taken at discrete values of local mean arterial pressure (Pmean), and a Cindex against Pmean plot is obtained. There is a statistically significant difference (p < 0.05) in Cindex for the lower values of Pmean (60-100 mmHg) between two age groups formed (15-52 and 58-73 years). The cold-pressor test (CPT) shows a 68% median decrease in Cindex, with an inter-quartile range of 60-77%, in a matter of seconds. The results suggest that Cindex may be a useful noninvasive indicator of peripheral vascular compliance in humans.
E A López-Beltrán; P L Blackshear; S M Finkelstein; J N Cohn
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Medical & biological engineering & computing     Volume:  36     ISSN:  0140-0118     ISO Abbreviation:  Med Biol Eng Comput     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1999-06-28     Completed Date:  1999-06-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7704869     Medline TA:  Med Biol Eng Comput     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  748-53     Citation Subset:  IM    
Biomedical Engineering Program, University of Minnesota, USA.
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MeSH Terms
Aging / physiology
Blood Pressure
Fingers / blood supply*
Middle Aged
Photoplethysmography / methods*
Grant Support
F31 GM 09586-06/GM/NIGMS NIH HHS

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