Document Detail

Non-invasive repeated measurement of urinary progesterone, 17beta-estradiol, and testosterone in developing, cycling, pregnant, and postpartum female mice.
MedLine Citation:
PMID:  15465115     Owner:  NLM     Status:  MEDLINE    
Excretory samples from adult female mice were collected non-invasively during development, estrous cycling, pregnancy, and postpartum. In initial studies, urinary measures were statistically more dynamic over days than were fecal measures; thus subsequent studies focused on urine. Higher 17beta-estradiol levels were present in isolated females than in those exposed to males. In cycling females, urinary 17beta-estradiol was more variable than were measures of testosterone or progesterone, showing peaks with an approximate 5-day periodicity. When urinary estradiol and progesterone were monitored in conjunction with vaginal smear cell counts, patterns were idiosyncratic; most females showed distinct peaks in urinary steroids, not in clear synchrony with vaginal cell cornification. Levels of progesterone rose markedly during the first 10 days of pregnancy, then declined before birth. Estradiol showed a substantial peak on days 7-8 of gestation in all females measured. Urinary testosterone was not dynamic during pregnancy, but rose in immediate prenatal and postpartum measures. During post-weaning, pre-pubertal development, urinary levels of progesterone remained constant but levels of estradiol rose substantially over time.
Denys deCatanzaro; Cameron Muir; Elliott A Beaton; Michelle Jetha
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Steroids     Volume:  69     ISSN:  0039-128X     ISO Abbreviation:  Steroids     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-10-06     Completed Date:  2005-03-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404536     Medline TA:  Steroids     Country:  United States    
Other Details:
Languages:  eng     Pagination:  687-96     Citation Subset:  IM    
Department of Psychology, McMaster University, Hamilton, Ont., Canada.
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MeSH Terms
Enzyme-Linked Immunosorbent Assay / methods
Estradiol / analysis,  urine
Estrous Cycle / urine*
Feces / chemistry
Gonadal Steroid Hormones / analysis,  urine*
Postpartum Period / urine*
Progesterone / analysis,  urine
Testosterone / analysis,  urine
Time Factors
Reg. No./Substance:
0/Gonadal Steroid Hormones; 50-28-2/Estradiol; 57-83-0/Progesterone; 58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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