Document Detail


Non-invasive quantification of peripheral arterial volume distensibility and its non-linear relationship with arterial pressure.
MedLine Citation:
PMID:  19345360     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Arterial wall function is associated with different physiological and clinical factors. Changes in arterial pressure cause major changes in the arterial wall. This study presents a simple non-invasive method to quantify arterial volume distensibility changes with different arterial pressures. The electrocardiogram, finger and ear photoplethysmogram were recorded from 15 subjects with the right arm at five different positions (90 degrees , 45 degrees , 0 degrees , -45 degrees and -90 degrees referred to the horizontal level). Arm pulse propagation time was determined by subtracting ear pulse transit time from finger pulse transit time, and was used to obtain arterial volume distensibility. The mean arterial blood pressure with the arm at the horizontal level was acquired, and changes with position were calculated using the hydrostatic principle that blood pressure in the arm is linearly related to its vertical distance from the horizontal level. The mean arm pulse propagation times for the five different positions were 88, 72, 57, 54 and 52ms, with the corresponding mean arterial volume distensibility of 0.234%, 0.158%, 0.099%, 0.088% and 0.083% per mmHg. For all consecutive changes in arm position, arm pulse propagation time and arterial volume distensibility, were significantly different (all probability P<0.05). The slopes of arm pulse propagation time and arterial volume distensibility against arterial pressure decreased significantly between each consecutive arm position from 90 degrees to -45 degrees (all P<0.01), indicating significant non-linearity. The experimental results fitted the physiological exponential model and Langewouters' arctangent model well, and were also comparable to published data with arterial volume distensibility approximately tripling for transmural pressure changes from 101 to 58mmHg. In conclusion, the inverse and non-linear relationship between arterial volume distensibility and arterial pressure has been quantified using a simple arm positioning procedure, with the greatest effect at low pressures. This work is an important step in developing a simple non-invasive technique for assessing peripheral arterial volume distensibility.
Authors:
Dingchang Zheng; Alan Murray
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-04-03
Journal Detail:
Title:  Journal of biomechanics     Volume:  42     ISSN:  1873-2380     ISO Abbreviation:  J Biomech     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-18     Completed Date:  2009-09-01     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0157375     Medline TA:  J Biomech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1032-7     Citation Subset:  IM    
Affiliation:
Medical Physics Department, Newcastle University, Freeman Hospital, Newcastle upon Tyne, UK. dingchang.zheng@ncl.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Arteries / physiology*
Blood Flow Velocity
Blood Pressure / physiology*
Female
Humans
Male
Middle Aged
Photoplethysmography
Pulsatile Flow / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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