Document Detail

Non-invasive pulmonary blood flow measurement by means of CO2 analysis of expiratory gases.
MedLine Citation:
PMID:  1907622     Owner:  NLM     Status:  MEDLINE    
Two different methods of CO2-derived non-invasive assessment of the pulmonary blood flow were evaluated. The principle of the formula, as proposed by Gedeon et al., is based on a rapid change in arterial CO2 content and subsequent changes in endtidal PCO2 and CO2 elimination. Both methods were compared to thermodilution cardiac output in 44 postoperative patients after CABG. The first method consisted of a short period of hyperventilation followed by hypoventilation. Comparison with the thermodilution cardiac output showed a low correlation coefficient: using a measured arterial--end-tidal PCO2 difference (E) r = 0.397 was found. Entering a fixed E of 0.53 kPa resulted in r = 0.454. These disappointing figures may be explained by procedural mistakes. The second method, based on partial rebreathing by means of adding an additional dead space of 220 ml for 30-45 s, correlated very well with the thermodilution findings. Correlation coefficients of r = 0.925 (measured E) and r = 0.925 (fixed E) were found. Considering the simplicity of the method, the additional dead space approach seems to be an easy and reliable way to determine pulmonary blood flow.
R J Bosman; C P Stoutenbeek; D F Zandstra
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Intensive care medicine     Volume:  17     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  1991  
Date Detail:
Created Date:  1991-09-11     Completed Date:  1991-09-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  98-102     Citation Subset:  IM; S    
Intensive Care Unit, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands.
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MeSH Terms
Breath Tests*
Carbon Dioxide / analysis*
Cardiac Output*
Coronary Artery Bypass
Evaluation Studies as Topic
Middle Aged
Positive-Pressure Respiration
Pulmonary Circulation*
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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