| Non-invasive positive pressure ventilation improves lung volumes in the obesity hypoventilation syndrome. | |
| | |
MedLine Citation:
|
PMID: 17166707 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Our objective was to study the long-term effects of non-invasive positive pressure ventilation (NPPV) on lung function and gas exchange in patients with the obesity hypoventilation syndrome (OHS). DESIGN: Prospective observational study in OHS patients performing NPPV over a period of 24 months. RESULTS: We studied 35 clinically stable OHS patients with a mean body mass index (BMI) 45.9+/-8.8 kg/m(2) and daytime PaCO(2) at room air of 6.92+/-0.48 kPa at baseline. Nocturnal NPPV was initiated with pressure-cycled devices on IPAP 24+/-3 cm H(2)O, EPAP 6+/-2 cm H(2)O and respiratory frequency of 18.8+/-3.7/min. After 12 and 24 months of NPPV hypercapnia was persistently normalized and hypoxemia was markedly improved while no changes in calculated alveolar-arterial oxygen difference occurred. Augmented ventilation was followed by a significant reduction in hemoglobin and hematocrit (P<0.001 each). Daily duration of ventilator use significantly correlated with the decrease in PaCO(2) after 12 months (r = 0.37; P<0.05) and 24 months (r = 0.47; P<0.05). Vital capacity (VC) and expiratory reserve volume (ERV) significantly increased after 12 and 24 months NPPV compared to the baseline values, though BMI was only slightly reduced. The 2-year survival rate was 91% with three patients (9%) discontinuing NPPV during the study period. CONCLUSION: Long-term domiciliary NPPV normalizes hypercapnia and markedly improves hypoxemia as well as polycythemia in OHS patients. In addition, NPPV leads to a significant reduction in restrictive ventilatory disturbance, predominantly by increasing ERV. Application of high inspiratory pressures and good adherence to therapy are presumed to be the basis for the beneficial effects of NPPV in OHS. |
| | |
Authors:
|
Frank Heinemann; Stephan Budweiser; Jakob Dobroschke; Michael Pfeifer |
Related Documents
:
|
6370597 - Functional residual capacity and lung mechanics at different levels of mechanical venti... 15957627 - Interactive simulation system for artificial ventilation on the internet: virtual venti... 12568167 - Implementation of a respiratory drive monitor on a servo ventilator. 3105567 - Assessment of a high frequency ventilator breathing system for use in the operating the... 1484937 - Postural fall in blood pressure in the elderly in relation to drug treatment and other ... 15312077 - Sperm competition and diversity in rodent copulatory behaviour. |
Publication Detail:
|
Type: Evaluation Studies; Journal Article Date: 2006-12-12 |
Journal Detail:
|
Title: Respiratory medicine Volume: 101 ISSN: 0954-6111 ISO Abbreviation: Respir Med Publication Date: 2007 Jun |
Date Detail:
|
Created Date: 2007-05-07 Completed Date: 2007-08-07 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8908438 Medline TA: Respir Med Country: England |
Other Details:
|
Languages: eng Pagination: 1229-35 Citation Subset: IM |
Affiliation:
|
Centre for Pneumology, Donaustauf Hospital, Ludwigstrasse 68, D-93093 Donaustauf, Germany. frank.heinemann@krankenhaus-donaustauf.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Anthropometry Body Mass Index Carbon Dioxide / blood Female Humans Male Middle Aged Obesity Hypoventilation Syndrome / physiopathology, therapy* Partial Pressure Patient Compliance Polycythemia / physiopathology, therapy Polysomnography Positive-Pressure Respiration / methods* Prospective Studies Pulmonary Gas Exchange Total Lung Capacity Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The morphology of adsorbed extracellular matrix assemblies is critically dependent on solution calci...
Next Document: Chemical and physical characterization of electrode materials of spent sealed Ni-Cd batteries.