Document Detail

Non-invasive neurally adjusted ventilatory assist in rabbits with acute lung injury.
MedLine Citation:
PMID:  17960364     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Neurally adjusted ventilatory assist uses the electrical activity of the diaphragm (EAdi)--a pneumatically-independent signal--to control the timing and pressure of the ventilation delivered, and should not be affected by leaks. The aim of this study was to evaluate whether NAVA can deliver assist in synchrony and proportionally to EAdi after extubation, with a leaky non-invasive interface. DESIGN AND SETTING: Prospective, controlled experimental study in an animal laboratory. ANIMALS: Ten rabbits, anesthetized, mechanically ventilated. INTERVENTIONS: Following lung injury, the following was performed in sequential order: (1) NAVA delivered via oral endotracheal tube with PEEP; (2) same as (1) without PEEP; (3) non-invasive NAVA at unchanged NAVA level and no PEEP via a single nasal prong; (4) no assist; (5) non-invasive NAVA at progressively increasing NAVA levels. MEASUREMENTS AND RESULTS: EAdi, esophageal pressure, blood gases and hemodynamics were measured during each condition. For the same NAVA level, the mean delivered pressure above PEEP increased from 3.9 +/ 1.4 cmH2O (intubated) to 7.5 +/- 3.8 cmH2O (non-invasive) (p<0.05) because of increased EAdi. No changes were observed in PaO2 and PaCO2. Increasing the NAVA level fourfold during non-invasive NAVA restored EAdi and esophageal pressure swings to pre-extubation levels. Triggering (106 +/- 20 ms) and cycling-off delays (40 +/- 21 ms) during intubation were minimal and not worsened by the leak (95 +/- 13 ms and 33 +/- 9 ms, respectively). CONCLUSION: NAVA can be effective in delivering non-invasive ventilation even when the interface with the patient is excessively leaky, and can unload the respiratory muscles while maintaining synchrony with the subject's demand.
Jennifer Beck; Lukas Brander; Arthur S Slutsky; Maureen C Reilly; Michael S Dunn; Christer Sinderby
Related Documents :
12163804 - Repeated derecruitments accentuate lung injury during mechanical ventilation.
10780034 - Effects of respiratory impedance on the performance of bi-level pressure ventilators.
2495904 - Pressure control inverse ratio ventilation as a method to reduce peak inspiratory press...
9762774 - Measurement of overinflation by multiple linear regression analysis in patients with ac...
23267374 - Impact of a community-based lifestyle intervention program on blood pressure and salt i...
23571074 - Safety climate dimensions as predictors for risk behavior.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-10-25
Journal Detail:
Title:  Intensive care medicine     Volume:  34     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-05     Completed Date:  2008-06-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  316-23     Citation Subset:  IM    
Sunnybrook Health Sciences Centre, Department of Newborn & Developmental Paediatrics, 76 Grenville, 4th floor (Paediatrics), M5S 1B6, Toronto, Ontario, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Analysis of Variance
Cardiac Output
Diaphragm / innervation,  physiopathology
Hydrochloric Acid
Positive-Pressure Respiration
Respiration, Artificial / methods*
Respiratory Distress Syndrome, Adult / etiology,  physiopathology,  therapy*
Tidal Volume
Grant Support
Reg. No./Substance:
7647-01-0/Hydrochloric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Primary hemiarthroplasty in proximal humerus fractures
Next Document:  The cannabinoid receptor agonists, anandamide and WIN 55,212-2, do not directly affect mu opioid rec...