Document Detail


Non-invasive monitoring of hepatocellular carcinoma in transgenic mouse with bioluminescent imaging.
MedLine Citation:
PMID:  21741167     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A small animal imaging system for hepatocellular carcinoma (HCC)-specific reporter gene expression will enable monitoring of carcinogenesis or therapeutic intervention in vivo. Transgenic mouse was developed in which firefly luciferase (fLuc) expression was controlled by the AFP enhancer/promoter. The bioluminescent signals of the transgenic neonates were strong at their liver region and decreased after birth. Bioluminescent imaging (BLI) of a transgenic mouse treated with N-nitrosodiethylamine revealed distinct fLuc activity in the liver and an increased pattern with time. The transgenic mouse model can be used to monitor AFP producing HCC by a chemical carcinogen in a live animal by BLI.
Authors:
Ju Hui Park; Kwang Il Kim; Yong Jin Lee; Tae Sup Lee; Kyeong Min Kim; Sang-Soep Nahm; Young-Seo Park; Gi Jeong Cheon; Sang Moo Lim; Joo Hyun Kang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-24
Journal Detail:
Title:  Cancer letters     Volume:  -     ISSN:  1872-7980     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-7-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences (KIRAMS), Seoul 139-706, Republic of Korea; Department of Food Science & Biotechnology, Kyungwon University, Gyeonggi-do 461-701, Republic of Korea.
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