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Non-invasive monitoring of central blood pressure by electrical impedance tomography: first experimental evidence.
MedLine Citation:
PMID:  21404079     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
There is a strong clinical demand for devices allowing continuous non-invasive monitoring of central blood pressure (BP). In the state of the art a new family of techniques providing BP surrogates based on the measurement of the so-called pulse wave velocity (PWV) has been proposed, eliminating the need for inflation cuffs. PWV is defined as the velocity at which pressure pulses propagate along the arterial wall. However, no technique to assess PWV within central arteries in a fully unsupervised manner has been proposed so far. In this pilot study, we provide first experimental evidence that electrical impedance tomography (EIT) is capable of measuring pressure pulses directly within the descending aorta. To obtain a wide range of BP values, we administrated noradrenalin and nitroglycerine to an anesthetized pig under mechanical ventilation. An arterial line was inserted into the ascending aorta for measuring reference BP. EIT images were generated from 32 impedance electrodes placed around the chest at the level of the axilla. Regions of Interest (ROI) such as the descending aorta and the lungs were automatically identified by a novel time-based processing algorithm as the respective EIT pixels representing these structures. The correct positions of these ROIs were confirmed by bolus injections of highly conductive concentrated saline into the right heart and into the ascending aorta. Aortic pulse transit time (PTT) values were determined as the delay between the opening of the aortic valve (obtained from arterial line) and the arrival of pressure pulses at the aortic ROI within the EIT plane. For 11 experimental conditions, with mean BP ranging from 73 to 141 mmHg, strongly significant correlation (r = -0.97, P < 0.00001) between central BP and aortic PTT was observed, suggesting that EIT-derived aortic PTT is a potential non-invasive surrogate of central BP.
Authors:
Josep Solà; Andy Adler; Arnoldo Santos; Gerardo Tusman; Fernando Suárez Sipmann; Stephan H Bohm
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-15
Journal Detail:
Title:  Medical & biological engineering & computing     Volume:  -     ISSN:  1741-0444     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704869     Medline TA:  Med Biol Eng Comput     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
CSEM-Centre Suisse d'Electronique et de Microtechnique, Neuchâtel, Switzerland, jsa@csem.ch.
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