Document Detail

Non-invasive methods and techniques for central blood pressure estimation: procedures, validation, reproducibility and limitations.
MedLine Citation:
PMID:  19149616     Owner:  NLM     Status:  MEDLINE    
Hypertension is a major risk factor for a wide range of cardiovascular diseases and is typically identified by measuring blood pressure (BP) at the brachial artery. Although such a measurement may accurately determine diastolic BP, it does not accurately reflect systolic BP. This is mainly attributed to the fact that blood pressure waveform is distorted as it travels outward from the heart due to the presence of wave reflections from the peripheral arteries. Due to this distortion, blood pressure measured at the brachial artery provides an inaccurate measure of central aortic systolic pressure. However, central systolic BP is an important factor determining cardiac function and work, while central diastolic BP may determine coronary flow. Consequently central (aortic and carotid) pressures are pathophysiologically more relevant than peripheral pressures and thus their non-invasive accurate estimation is challenging and clinically necessary. The purpose of this review is to present methods and techniques that are used for the estimation of central blood pressures and to describe and discuss issues regarding methodological procedures, reproducibility, validity and limitations.
Theodore G Papaioannou; Athanassios D Protogerou; Kimon S Stamatelopoulos; Manolis Vavuranakis; Christodoulos Stefanadis
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current pharmaceutical design     Volume:  15     ISSN:  1873-4286     ISO Abbreviation:  Curr. Pharm. Des.     Publication Date:  2009  
Date Detail:
Created Date:  2009-01-19     Completed Date:  2009-04-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602487     Medline TA:  Curr Pharm Des     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  245-53     Citation Subset:  IM    
Biomedical Engineering Unit, 1st Dept. of Cardiology, Hippokration Hospital, Medical School, National & Kapodistrian University of Athens, Greece.
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MeSH Terms
Blood Pressure*
Blood Pressure Determination / methods
Brachial Artery*
Cardiovascular Diseases / etiology
Hypertension / complications,  diagnosis*,  physiopathology
Reproducibility of Results
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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