| Non-invasive measurement of the morphology and physiology of oral mucosa by use of optical spectroscopy. | |
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MedLine Citation:
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PMID: 17350324 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Differential path-length spectroscopy (DPS) was used to non-invasively determine the superficial optical properties of oral mucosa in vivo. DPS yields information on physiological parameters such as the mucosal blood content, the microvascular blood oxygenation and the average micro-vessel diameter as well as on morphological parameters such as the scattering slope and scattering amplitude. DPS measurements were made on normal and cancerous oral mucosa using a novel fiber-optic probe, and were correlated to the histological outcome of punch biopsies taken from the same location. Our data shows that the mucosa of oral squamous cell carcinoma is characterised by a significant decrease in microvascular oxygenation and increase in mucosal blood content compared to normal oral mucosa as well as a significant decrease in scattering amplitude and increase in scattering slope. |
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Authors:
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A Amelink; O P Kaspers; H J C M Sterenborg; J E van der Wal; J L N Roodenburg; M J H Witjes |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-03-09 |
Journal Detail:
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Title: Oral oncology Volume: 44 ISSN: 1368-8375 ISO Abbreviation: Oral Oncol. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2007-12-18 Completed Date: 2008-08-04 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9709118 Medline TA: Oral Oncol Country: England |
Other Details:
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Languages: eng Pagination: 65-71 Citation Subset: IM |
Affiliation:
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Center for Optical Diagnostics and Therapy, Department of Radiation Oncology, Erasmus Medical Centre, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Carcinoma, Squamous Cell / blood supply, pathology* Female Fiber Optic Technology / instrumentation Humans Male Middle Aged Mouth Mucosa / anatomy & histology, pathology* Mouth Neoplasms / blood supply, pathology* Optical Fibers Oxygen / blood Spectrum Analysis / instrumentation, methods |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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