Document Detail


Non-invasive measurement of local pulse pressure by pulse wave-based ultrasound manometry (PWUM).
MedLine Citation:
PMID:  21904023     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Central blood pressure (CBP) has been established as a relevant indicator of cardiovascular disease. Despite its significance, CBP remains particularly challenging to measure in standard clinical practice. The objective of this study is to introduce pulse wave-based ultrasound manometry (PWUM) as a simple-to-use, non-invasive ultrasound-based method for quantitative measurement of the central pulse pressure. Arterial wall displacements are estimated using radiofrequency ultrasound signals acquired at high frame rates and the pulse pressure waveform is estimated using both the distension waveform and the local pulse wave velocity. The method was tested on the abdominal aorta of 11 healthy subjects (age 35.7 ± 16 y.o.). PWUM pulse pressure measurements were compared to those obtained by radial applanation tonometry using a commercial system. The average intra-subject variability of the pulse pressure amplitude was found to be equal to 4.2 mmHg, demonstrating good reproducibility of the method. Excellent correlation was found between the waveforms obtained by PWUM and those obtained by tonometry in all subjects (0.94 < r < 0.98). A significant bias of 4.7 mmHg was found between PWUM and tonometry. PWUM is a highly translational method that can be easily integrated in clinical ultrasound imaging systems. It provides an estimate of the pulse pressure waveform at the imaged location, and may offer therefore the possibility to estimate the pulse pressure at different arterial sites. Future developments include the validation of the method against invasive estimates on patients, as well as its application to other large arteries.
Authors:
J Vappou; J Luo; K Okajima; M Di Tullio; E E Konofagou
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-09-09
Journal Detail:
Title:  Physiological measurement     Volume:  32     ISSN:  1361-6579     ISO Abbreviation:  Physiol Meas     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-23     Completed Date:  2012-01-11     Revised Date:  2014-05-15    
Medline Journal Info:
Nlm Unique ID:  9306921     Medline TA:  Physiol Meas     Country:  England    
Other Details:
Languages:  eng     Pagination:  1653-62     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Arteries / physiology
Blood Pressure / physiology*
Humans
Manometry / methods*
Middle Aged
Reproducibility of Results
Ultrasonics / methods*
Wavelet Analysis*
Young Adult
Grant Support
ID/Acronym/Agency:
R01 EB006042/EB/NIBIB NIH HHS; R01 HL098830/HL/NHLBI NIH HHS; R01EB006042/EB/NIBIB NIH HHS; R01HL098830/HL/NHLBI NIH HHS
Comments/Corrections

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