Document Detail


Non-invasive investigation of cerebral metabolism in newborn infants by phosphorus nuclear magnetic resonance spectroscopy.
MedLine Citation:
PMID:  6133102     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intracellular metabolism in the brains of seven infants, born at 33-40 weeks' gestation and aged 44 h to 17 days, was studied on fourteen occasions by phosphorus nuclear magnetic resonance spectroscopy (31P NMRS). The characteristic spectral peaks of ATP, phosphocreatine (PCr), phosphodiesters, and inorganic orthophosphate (Pi) were always detected, together with a large peak attributed mainly to ribose-5-phosphate. The ratio of PCr to Pi NMRS signals (which are related to concentration) in one infant thought to have a normal brain was 1.7. In three infants who had severe birth asphyxia the PCr/Pi ratio ranged from 0.2 to 1.0 but increased as their clinical condition improved: infusions of mannitol solution caused a rapid increase in the ratio on four occasions in two of these infants. The PCr/Pi ratio was 1.4 in an infant with congenital cerebral atrophy and 0.7 in an infant with meningitis. Grossly abnormal 31P spectra antedated the detection by ultrasound of large porencephalic cysts in two infants. No systematic changes in intracellular pH (calculated from the chemical shift of the Pi resonance) were observed: the mean value for all observations was 7.2 +/- SD 0.1 (n = 14).
Authors:
E B Cady; A M Costello; M J Dawson; D T Delpy; P L Hope; E O Reynolds; P S Tofts; D R Wilkie
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lancet     Volume:  1     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1983 May 
Date Detail:
Created Date:  1983-06-23     Completed Date:  1983-06-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1059-62     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / metabolism
Asphyxia Neonatorum / diagnosis,  metabolism
Brain / metabolism*
Female
Humans
Hypoxia, Brain / diagnosis,  metabolism
Infant, Newborn
Infant, Newborn, Diseases / diagnosis,  metabolism*
Magnetic Resonance Spectroscopy*
Male
Phosphocreatine / metabolism
Phosphorus
Ribosemonophosphates / metabolism
Spectrum Analysis
Chemical
Reg. No./Substance:
0/Ribosemonophosphates; 3615-55-2/ribose-5-phosphate; 56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine; 7723-14-0/Phosphorus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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