Document Detail


Non invasive in vivo study of the maturation of CYP IIIA in neonates and infants.
MedLine Citation:
PMID:  8880054     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Cytochrome P450 III (CYP III) has previously been demonstrated in vitro in fetal liver. METHODS: A study was performed in 7 premature, 13 term neonates and 30 infants to assess whether or not maturation had any influence on CYP IIIA activity in children from birth to 1 year of age. A simple non invasive procedure was used (6 beta OHF/FF concentration ratio in a morning spot urine sample). RESULTS: The 6 beta OHF/FF ratio was 7.2, 7.9 and 5.0 in premature and term neonates and infants, respectively. CYP IIIA activity is present at birth, with a 6 beta OHF/FF ratio comparable to adults. Its activity seemed lower in infants. This might be due to the decrease in CYP IIIA7 activity during maturation after birth, which might be more rapid than the increase in CYP IIIA3/4 activity.
Authors:
F Vauzelle-Kervroedan; E Rey; A Pariente-Khayat; T Bienvenu; J Badoual; G Olive; G Pons
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  51     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1996  
Date Detail:
Created Date:  1997-01-21     Completed Date:  1997-01-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  69-72     Citation Subset:  IM    
Affiliation:
Département de Pharmacologie Clinique Périnatale et Pediatrique, Hôpital Saint-Vincent de Paul, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Aryl Hydrocarbon Hydroxylases*
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System / metabolism*,  urine
Female
Humans
Infant
Infant, Newborn
Liver / enzymology*
Male
Oxidoreductases, N-Demethylating / metabolism*,  urine
Regression Analysis
Chemical
Reg. No./Substance:
9035-51-2/Cytochrome P-450 Enzyme System; EC 1.14.14.1/Aryl Hydrocarbon Hydroxylases; EC 1.14.14.1/Cytochrome P-450 CYP3A; EC 1.5.-/Oxidoreductases, N-Demethylating

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