| Non invasive in vivo study of the maturation of CYP IIIA in neonates and infants. | |
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MedLine Citation:
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PMID: 8880054 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Cytochrome P450 III (CYP III) has previously been demonstrated in vitro in fetal liver. METHODS: A study was performed in 7 premature, 13 term neonates and 30 infants to assess whether or not maturation had any influence on CYP IIIA activity in children from birth to 1 year of age. A simple non invasive procedure was used (6 beta OHF/FF concentration ratio in a morning spot urine sample). RESULTS: The 6 beta OHF/FF ratio was 7.2, 7.9 and 5.0 in premature and term neonates and infants, respectively. CYP IIIA activity is present at birth, with a 6 beta OHF/FF ratio comparable to adults. Its activity seemed lower in infants. This might be due to the decrease in CYP IIIA7 activity during maturation after birth, which might be more rapid than the increase in CYP IIIA3/4 activity. |
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Authors:
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F Vauzelle-Kervroedan; E Rey; A Pariente-Khayat; T Bienvenu; J Badoual; G Olive; G Pons |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of clinical pharmacology Volume: 51 ISSN: 0031-6970 ISO Abbreviation: Eur. J. Clin. Pharmacol. Publication Date: 1996 |
Date Detail:
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Created Date: 1997-01-21 Completed Date: 1997-01-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1256165 Medline TA: Eur J Clin Pharmacol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 69-72 Citation Subset: IM |
Affiliation:
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Département de Pharmacologie Clinique Périnatale et Pediatrique, Hôpital Saint-Vincent de Paul, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aryl Hydrocarbon Hydroxylases* Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System / metabolism*, urine Female Humans Infant Infant, Newborn Liver / enzymology* Male Oxidoreductases, N-Demethylating / metabolism*, urine Regression Analysis |
| Chemical | |
Reg. No./Substance:
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9035-51-2/Cytochrome P-450 Enzyme System; EC 1.14.14.1/Aryl Hydrocarbon Hydroxylases; EC 1.14.14.1/Cytochrome P-450 CYP3A; EC 1.5.-/Oxidoreductases, N-Demethylating |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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