Document Detail


Noninvasive follow-up of simian immunodeficiency virus infection in wild-living nonhabituated western lowland gorillas in Cameroon.
MedLine Citation:
PMID:  22740419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Simian immunodeficiency viruses infecting western lowland gorillas (SIVgor) are closely related to HIV-1 and are most likely the ancestors of HIV-1 groups O and P. At present, limited data are available on genetic diversity, transmission, viral evolution, and pathogenicity of SIVgor in its natural host. Between 2004 and 2011, 961 putative gorilla fecal samples were collected at the Campo Ma'an National Park, Cameroon. Among them, 16% cross-reacted with HIV-1 antibodies, corresponding to at least 34 infected gorillas. Combining host genotyping and field data, we identified four social groups composed of 7 to 15 individuals each, with SIV rates ranging from 13% to 29%. Eleven SIVgor-infected gorillas were sampled multiple times; two most likely seroconverted during the study period, showing that SIVgor continues to spread. Phylogenetic analysis of partial env and pol sequences revealed cocirculation of closely related and divergent strains among gorillas from the same social group, indicating SIVgor transmissions within and between groups. Parental links could be inferred for some gorillas infected with closely related strains, suggesting vertical transmission, but horizontal transmission by sexual or aggressive behavior was also suspected. Intrahost molecular evolution in one gorilla over a 5-year period showed viral adaptations characteristic of escape mutants, i.e., V1V2 loop elongation and an increased number of glycosylation sites. Here we show for the first time the feasibility of noninvasive monitoring of nonhabituated gorillas to study SIVgor infection over time at both the individual and population levels. This approach can also be applied more generally to study other pathogens in wildlife.
Authors:
Lucie Etienne; Sabrina Locatelli; Ahidjo Ayouba; Amandine Esteban; Christelle Butel; Florian Liegeois; Avelin Aghokeng; Eric Delaporte; Eitel Mpoudi Ngole; Martine Peeters
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-06-27
Journal Detail:
Title:  Journal of virology     Volume:  86     ISSN:  1098-5514     ISO Abbreviation:  J. Virol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-27     Completed Date:  2012-11-21     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  9760-72     Citation Subset:  IM    
Affiliation:
UMI233, TransVIHMI, Institut de Recherche pour le Développement (IRD) and Université Montpellier 1, Montpellier, France.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/JQ924140;  JQ924141;  JQ924142;  JQ924143;  JQ924144;  JQ924145;  JQ924146;  JQ924147;  JQ924148;  JQ924149;  JQ924150;  JQ924151;  JQ924152;  JQ924153;  JQ924154;  JQ924155;  JQ924156;  JQ924157;  JQ924158;  JQ924159;  JQ924160;  JQ924161;  JQ924162;  JQ924163;  JQ924164;  JQ924165;  JQ924166;  JQ924167;  JQ924168;  JQ924169;  JQ924170;  JQ924171;  JQ924172;  JQ924173;  JQ924174;  JQ924175;  JQ924176;  JQ924177;  JQ924178;  JQ924179;  JQ924180;  JQ924181;  JQ924182;  JQ924183;  JQ924184;  JQ924185;  JQ924186;  JQ924187
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Wild / immunology,  virology
Antibodies, Viral / analysis
Base Sequence
Cameroon
DNA, Viral / genetics
Disease Transmission, Infectious / veterinary
Feces / chemistry
Female
Follow-Up Studies
Genes, env
Genes, pol
Genetic Variation
Gorilla gorilla* / immunology,  virology
HIV-1 / genetics
Host-Pathogen Interactions
Infectious Disease Transmission, Vertical / veterinary
Male
Membrane Glycoproteins / genetics
Molecular Sequence Data
Phylogeny
Pregnancy
Simian Acquired Immunodeficiency Syndrome / immunology,  transmission,  virology*
Simian immunodeficiency virus / classification,  genetics*,  immunology
Viral Envelope Proteins / genetics
Grant Support
ID/Acronym/Agency:
R01 AI50529/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Viral; 0/DNA, Viral; 0/Membrane Glycoproteins; 0/Viral Envelope Proteins; 0/gp120 protein, Simian immunodeficiency virus
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