| Non-invasive evaluation of the myocardial substrate of cardiac amyloidosis by gadolinium cardiac magnetic resonance. | |
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MedLine Citation:
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PMID: 15939726 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the prevalence and distribution of gadolinium (Gd) enhancement at cardiac magnetic resonance (CMR) imaging in patients with cardiac amyloidosis (CA) and to look for associations with clinical, morphological, and functional features. PATIENTS AND DESIGN: 21 patients with definitely diagnosed CA (nine with immunoglobulin light chain amyloidosis and 12 transthyretin related) underwent Gd-CMR. RESULTS: Gd enhancement was detected in 16 of 21 (76%) patients. Sixty six of 357 (18%) segments were enhanced, more often at the mid ventricular level. Transmural extension of enhancement within each patient significantly correlated with left ventricular (LV) end systolic volume (r = 0.58). The number of enhanced segments correlated with LV end diastolic volume (r = 0.76), end systolic volume (r = 0.6), and left atrial size (r = 0.56). Segments with > 50% extensive transmural enhancement more often were severely hypokinetic or akinetic (p = 0.001). Patients with > 2 enhanced segments had significantly lower 12 lead QRS voltage and Sokolow-Lyon index. No relation was apparent with any other clinical, morphological, functional, or histological characteristics. CONCLUSION: Gd enhancement is common but not universally present in CA, probably due to expansion of infiltrated interstitium. The segmental and transmural distribution of the enhancement is highly variable, and mid-ventricular regions are more often involved. Enhancement appears to be associated with impaired segmental and global contractility and a larger atrium. |
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Authors:
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E Perugini; C Rapezzi; T Piva; O Leone; L Bacchi-Reggiani; L Riva; F Salvi; L Lovato; A Branzi; R Fattori |
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Publication Detail:
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Type: Journal Article Date: 2005-06-06 |
Journal Detail:
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Title: Heart (British Cardiac Society) Volume: 92 ISSN: 1468-201X ISO Abbreviation: Heart Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-02-27 Completed Date: 2006-04-10 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 9602087 Medline TA: Heart Country: England |
Other Details:
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Languages: eng Pagination: 343-9 Citation Subset: AIM; IM |
Affiliation:
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Institute of Cardiology, University of Bologna, S Orsola-Malpighi Hospital, Bologna, Italy. e_perugini@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amyloidosis
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diagnosis* Cardiomyopathies / diagnosis* Female Gadolinium / diagnostic use* Humans Magnetic Resonance Angiography / methods* Magnetic Resonance Imaging, Cine Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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7440-54-2/Gadolinium |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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