| Non-invasive evaluation of the fibrosis stage in chronic hepatitis C: a comparative analysis of nine scoring methods. | |
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MedLine Citation:
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PMID: 20030577 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Liver biopsy is an invasive procedure and new surrogate markers to assess fibrosis are needed. We performed a comparative external evaluation of nine non-invasive scores of liver fibrosis and tried to identify other potential biochemical markers of low-stage liver fibrosis in chronic hepatitis C (CHC). MATERIAL AND METHODS: We included 429 previously untreated consecutive patients from a single centre who underwent a liver biopsy between January 1999 and April 2009. Biopsies were evaluated for the stage of fibrosis according to the METAVIR scoring method. RESULTS: None of the evaluated scores were adequate to disclose null-low fibrosis due to a lack of specificity at the proposed cut-offs and the poor sensitivity of lower cut-offs. Serum ferritin and cholesterol values were found to be independently related to the fibrosis stage and their inclusion in the best performing scores at lower cut-off values (the APRI and King's scores) improved the sensitivity for null-low fibrosis by 8% with a specificity >or= 93%. CONCLUSIONS: Approximately 30% of patients with null-low fibrosis may be accurately identified by supplementing current scores with new independent variables (serum ferritin and cholesterol), thus obviating the need for a liver biopsy. |
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Authors:
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Jos? M Ladero; Jaime Delkader; Luis Ortega; Cristina Fern?ndez; Mar?a J Devesa; Gustavo L?pez-Alonso; Julio Mayol; Francisca Cuenca; Avelina Su?rez; Carlos Taxonera; Manuel D?az-Rubio |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian journal of gastroenterology Volume: 45 ISSN: 1502-7708 ISO Abbreviation: Scand. J. Gastroenterol. Publication Date: 2010 |
Date Detail:
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Created Date: 2009-12-24 Completed Date: 2010-03-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0060105 Medline TA: Scand J Gastroenterol Country: England |
Other Details:
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Languages: eng Pagination: 51-9 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Hospital Cl?nico San Carlos, Universidad Complutense, Madrid, Spain. jladero.hcsc@salud.madrid.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Hepatitis C, Chronic / complications* Humans Liver Cirrhosis / etiology*, pathology* Male Middle Aged Sensitivity and Specificity Severity of Illness Index |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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