Document Detail

Non-invasive estimation of pulmonary capillary wedge pressure at rest and during exercise by electrocardiography, phonocardiography and Doppler echocardiography.
MedLine Citation:
PMID:  3188984     Owner:  NLM     Status:  MEDLINE    
Non-invasive estimation of the mean pulmonary capillary wedge pressure was accomplished by simultaneous electrocardiographic, phonocardiographic and continuous wave Doppler echocardiographic recordings. The interval from the onset of the QRS complex to the Doppler determined mitral valve closure (Q-MC) and the interval from the phonocardiographic aortic component of the second heart sound to the Doppler determined mitral valve opening (A2-MO) were measured. The non-invasive registrations were carried out simultaneously with direct measurements of the wedge pressure. In an initial group of 22 patients, a significant correlation was observed between the intervals alone and the wedge pressure, r = 0.60, SEE = +/- 6.9 mmHg, p less than 0.01, for the Q-MC interval and r = -0.70, SEE = 6.2 mmHg, p less than 0.001 for the A2-MO interval. A closer correlation was observed between the ratio Q-MC/A2-MO and the measured wedge pressure, r = 0.93, SEE = +/- 3.1 mmHg, p less than 0.001. The linear regression equation, PCW = 19.5 (Q-MC/A2-MO) + 3.0 (mmHg), was applied prospectively to a second group of 23 patients. Again the relationship between estimated and measured wedge pressure was highly significant, r = 0.90, SEE = +/- 3.1 mmHg, p less than 0.001. Twenty-two patients were also studied during an exercise test, and acceptable non-invasive recordings were obtained in 19 of them. The change in estimated wedge pressure during activity related closely to the change in actual wedge pressure, r = 0.80, SEE = +/- 5.7 mmHg, p less than 0.001. A simplified equation suitable for routine clinical practice, PCW = 24 (Q-MC/A2-MO) (mmHg), yielded almost equally accurate estimates of the wedge pressure over a wide range of pressures. The simplicity and reasonable accuracy of Doppler-assisted estimation of the wedge pressure makes it useful in the evaluation and follow-up of patients with suspected cardiac disorders. The method may assist in evaluating the effects of diagnostic or therapeutic procedures, since it is sufficiently sensitive to detect acute directional changes in wedge pressure.
K Karp; D Teien; P Eriksson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta medica Scandinavica     Volume:  224     ISSN:  0001-6101     ISO Abbreviation:  Acta Med Scand     Publication Date:  1988  
Date Detail:
Created Date:  1988-12-16     Completed Date:  1988-12-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370330     Medline TA:  Acta Med Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  337-42     Citation Subset:  IM    
Department of Clinical Physiology, University Hospital, Umeå, Sweden.
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MeSH Terms
Echocardiography, Doppler*
Heart Catheterization
Heart Diseases / physiopathology
Middle Aged
Prospective Studies
Pulmonary Wedge Pressure*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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