Document Detail

Non-invasive diagnosis of coronary artery disease by (123)I-BMIPP/(201)TlCl dual myocardial SPECT in patients with heart failure.
MedLine Citation:
PMID:  25205480     Owner:  NLM     Status:  Publisher    
BACKGROUND/OBJECTIVES: Detecting the presence of coronary artery disease (CAD) is critically important in managing patients with heart failure of uncertain cause. The recently introduced (123)I-BMIPP/(201)TlCl dual myocardial single-photon emission computed tomography (dual SPECT) is potentially a non-invasive diagnostic tool in detecting ischemic heart disease. The aim of our study is to evaluate the efficacy of detecting CAD by dual SPECT in patients with heart failure.
METHODS: We studied 501 consecutive patients (366 males, mean age 68±12years) who were admitted because of heart failure between January 2005 and April 2009. In all patients, the dual SPECT was performed in clinically stabilized states, followed by coronary angiography within 1week. The polar map of the SPECT image was divided into 17 segments, each scored on a scale of 0-4 based on segmental percent uptake. The mismatch score was defined as the difference between (123)I-BMIPP defect score and (201)TlCI defect score. The uptake of (201)TlCl and (123)I-BMIPP was analyzed quantitatively using the Heart Score View software.
RESULTS: The (201)TlCI defect score and mismatch score were significantly higher in CAD patients than in non-CAD patients. The receiver operating characteristic (ROC) curve revealed that the mismatch score was a significantly more effective marker in detecting the presence of CAD than (201)TlCl defect score (area under the curve: 0.84 versus 0.73, p<0.05). Using the mismatch score, the sensitivity and specificity of dual SPECT in detecting CAD were 84% and 83%, respectively.
CONCLUSION: Dual SPECT is a useful non-invasive procedure for the detection of CAD in patients with heart failure.
Hajime Abe; Nobuo Iguchi; Yuko Utanohara; Kanki Inoue; Itaru Takamisawa; Atsushi Seki; Kouhei Tanizaki; Norihiko Takeda; Tetsuya Tohbaru; Ryuta Asano; Masatoshi Nagayama; Morimasa Takayama; Jun Umemura; Tetsuya Sumiyoshi; Hitonobu Tomoike
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-29
Journal Detail:
Title:  International journal of cardiology     Volume:  -     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-9-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.
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