| Non-invasive detection and quantification of human foetal brain lactate in utero by magnetic resonance spectroscopy. | |
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MedLine Citation:
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PMID: 20120007 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the feasibility of foetal cerebral lactate detection and quantification by proton magnetic resonance spectroscopy ((1)H-MRS) in pregnancies at increased risk of cerebral hypoxia, using a clinical 1.5 T magnetic resonance imaging (MRI) system. METHOD: Localised (1)H-MRS was performed in four patients with pregnancies in their third trimester complicated by intrauterine growth restriction (IUGR). A long echo time (TE) of 288 ms was used to maximise detection and conspicuity of the lactate methyl resonance, together with a short TE MRS acquisition to check for the presence of lipid contamination. Individual peaks in the resulting spectra were measured, corrected for relaxation and referenced to the unsuppressed water signal to provide metabolite concentrations. RESULTS: A resonance peak consistent with the presence of lactate was observed in all cases. In one subject, this was confounded by the identification of significant lipid contamination in the short TE MRS acquisition. The range of measured lactate concentrations was 2.0-3.3 mmol/kg and compared well with preterm neonatal MRS studies. CONCLUSION: The non-invasive detection and quantification of foetal cerebral lactate by MRS is achievable on a clinical 1.5 T MRI system. |
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Authors:
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Geoffrey D Charles-Edwards; Wajanat Jan; Meekai To; Darryl Maxwell; Stephen F Keevil; Richard Robinson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Prenatal diagnosis Volume: 30 ISSN: 1097-0223 ISO Abbreviation: Prenat. Diagn. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-01 Completed Date: 2010-06-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: England |
Other Details:
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Languages: eng Pagination: 260-6 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Medical Physics, Guy's & St Thomas' NHS Foundation Trust, London, UK. geoff.charles-edwards@kcl.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / analysis Brain / embryology, metabolism* Brain Chemistry Female Fetal Growth Retardation / metabolism Fetal Hypoxia / diagnosis, metabolism Fetus / metabolism* Humans Hypoxia, Brain / embryology, metabolism* Lactic Acid / analysis, metabolism* Magnetic Resonance Imaging / instrumentation Magnetic Resonance Spectroscopy / methods* Placental Insufficiency / diagnosis, metabolism Pregnancy Pregnancy Trimester, Third |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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