Document Detail


Non-invasive detection of coronary artery disease by body surface electrocardiographic mapping after dipyridamole infusion.
MedLine Citation:
PMID:  3746148     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Electrocardiographic changes after dipyridamole infusion (0.568 mg/kg/4 min) were studied in 41 patients with coronary artery disease and compared with those after submaximal treadmill exercise by use of the body surface mapping technique. Patients were divided into three groups; 19 patients without myocardial infarction (non-MI group), 14 with anterior infarction (ANT-MI) and eight with inferior infarction (INF-MI). Eighty-seven unipolar electrocardiograms (ECGs) distributed over the entire thoracic surface were simultaneously recorded. After dipyridamole, ischemic ST-segment depression (0.05 mV or more) was observed in 84% of the non-MI group, 29% of the ANT-MI group, 63% of the INF-MI group and 61% of the total population. Exercise-induced ST depression was observed in 84% of the non-MI group, 43% of the ANT-MI group, 38% of the INF-MI group and 61% of the total. For individual patients, there were no obvious differences between the body surface distribution of ST depression in both tests. The increase in pressure rate product after dipyridamole was significantly less than that during the treadmill exercise. The data suggest that the dipyridamole-induced myocardial ischemia is caused by the inhomogenous distribution of myocardial blood flow. We conclude that the dipyridamole ECG test is as useful as the exercise ECG test for the assessment of coronary artery disease.
Authors:
K Ikeda; S Kawashima; I Kubota; A Igarashi; M Yamaki; S Yasumura; K Tsuiki; S Yasui
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of electrocardiology     Volume:  19     ISSN:  0022-0736     ISO Abbreviation:  J Electrocardiol     Publication Date:  1986 Jul 
Date Detail:
Created Date:  1986-10-20     Completed Date:  1986-10-20     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0153605     Medline TA:  J Electrocardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  213-23     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Pressure
Coronary Disease / diagnosis*
Dipyridamole / diagnostic use*
Electrocardiography / methods*
Exercise Test
Female
Heart Rate
Humans
Male
Middle Aged
Myocardial Infarction / diagnosis
Chemical
Reg. No./Substance:
58-32-2/Dipyridamole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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