Document Detail

Non-invasive bioengineering methods in an intervention study in 1020 male metal workers: results and implications for occupational dermatology.
MedLine Citation:
PMID:  20536474     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Measurements of transepidermal water loss (TEWL) as an indicator of skin barrier function and colorimetry for quantifying erythema have been recommended for monitoring persons at risk of occupational hand dermatitis. OBJECTIVE: This study examines the practicability and usefulness of biophysical measurements at the workplace. PATIENTS/MATERIAL/METHODS: A sample of 1020 male metal workers was enrolled; 800 participants were followed up for 1 year. TEWL results and colorimetry (a* value), respectively, were used as effectiveness outcomes, comparing the findings in the four study arms (skin care, skin protection, both combined, and control group). RESULTS: At 1 year follow-up, the TEWL was slightly but significantly lower in the group of participants randomized for application of barrier cream alone, indicating a protective effect. However, addressing both the individual absolute change of a* value and the differences of TEWL (delta-TEWL) of the dominant hand over the study period, no significant difference was found between the four groups. CONCLUSIONS: Dermatological examinations at the workplace cannot be replaced by bioengineering techniques. The supplementary benefit is apparently low, possibly because of difficulties in achieving standardized measurement conditions and other technical reasons.
Birgitta Kütting; Wolfgang Uter; Thomas Baumeister; Barbara Schaller; Wobbeke Weistenhöfer; Hans Drexler
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Contact dermatitis     Volume:  62     ISSN:  1600-0536     ISO Abbreviation:  Contact Derm.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-06-11     Completed Date:  2010-09-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7604950     Medline TA:  Contact Dermatitis     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  272-8     Citation Subset:  IM    
Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich-Alexander-University of Erlangen-Nuremberg, Erlangen, Germany.
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MeSH Terms
Bioengineering / methods*
Dermatitis, Occupational / diagnosis*,  pathology,  prevention & control
Erythema / diagnosis*,  pathology,  prevention & control
Hand Dermatoses / diagnosis*,  pathology,  prevention & control
Middle Aged
Monitoring, Physiologic / methods*
Prospective Studies
Treatment Outcome
Water Loss, Insensible*
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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