Document Detail

Noninvasive bioengineering assessment of the skin barrier function in patients with chronic venous insufficiency.
MedLine Citation:
PMID:  20105166     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Chronic venous insufficiency (CVI) comprises all symptoms caused by permanent venous and capillary hypertension. While the clinical manifestations of the disease have been well characterized, there is little knowledge on the skin barrier function in the affected patients. OBJECTIVES: The aim of the study was to assess noninvasively the barrier function in patients with CVI stage C2 and stage C4 according to the CEAP classification in comparison with healthy controls (stage C0). METHODS: Thirty patients with CVI without concomitant diseases and 15 healthy, aged-matched controls were recruited for the study. The skin barrier function was assessed by measuring transepidermal water loss (TEWL), capacitance and skin colour symmetrically on the calf, medial and lateral malleolus, posterior arch (arcus venosus) and volar forearm. RESULTS: Compared with the forearm, there was a tendency for increased TEWL and significant reduction of capacitance on all measurement sites on the lower limb. Compared with the control group, the patients with CVI had significantly higher TEWL values on all measurement sites on the lower extremities while no difference in capacitance between patients and controls was observed. CONCLUSIONS: Changes in the epidermal barrier function in patients with CVI are readily detectable by bioengineering methods as early as stage C2 and are manifested by significantly increased TEWL. Our results suggest that the reduced stratum corneum hydration in patients with CVI is due to anatomical differences rather than venous disease. These findings may help better understand the factors contributing to disease progression and its complications.
I Angelova-Fischer; D Wuthe; D Zillikens; B Kahle
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Publication Detail:
Type:  Journal Article     Date:  2010-01-22
Journal Detail:
Title:  The British journal of dermatology     Volume:  162     ISSN:  1365-2133     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-28     Completed Date:  2010-06-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1071-5     Citation Subset:  IM    
Department of Dermatology, University of L?beck, Ratzeburger Allee 160, L?beck, Germany.
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MeSH Terms
Bioengineering / methods
Chronic Disease
Galvanic Skin Response / physiology
Middle Aged
Skin / physiopathology*
Skin Pigmentation / physiology
Varicose Veins / physiopathology
Venous Insufficiency / physiopathology*
Water Loss, Insensible / physiology*

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