Document Detail

Non-invasive assessment of plaque rupture by 64-slice multidetector computed tomography--comparison with intravascular ultrasound.
MedLine Citation:
PMID:  18654013     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Plaque rupture and secondary thrombus formation play key roles in the onset of acute coronary syndrome (ACS). Multidetector computed tomography (MDCT) allows the non-invasive assessment of coronary artery stenosis and plaque properties. In this study, we investigated whether 64-slice MDCT could non-invasively detect a plaque rupture in patients with de novo angina. METHODS AND RESULTS: The study population comprised 67 patients with de novo angina. All patients underwent contrast-enhanced 64-slice MDCT and intravascular ultrasound (IVUS). Patients were divided into a plaque rupture group (n=27) and a non-rupture group (n=40) based on the IVUS. The 64-slice MDCT revealed that the prevalence of an ulcer-like enhancement space (37% vs 5%, p<0.01), a ring-like sign (41% vs 18%, p=0.04), in the plaque rupture group was higher than those in the non-rupture group. Maximum plaque thickness (2.1+/-0.9 mm vs 1.6+/-1.0 mm, p=0.04), outer vessel area (17.6+/-4.9 mm2 vs 13.4+/-5.0 mm2, p<0.01), percentage plaque area (82.3+/-9.1% vs 73.4+/-15.7%, p=0.01), and remodeling index (1.11+/-0.18 vs 1.01+/-0.15, p=0.04) of the plaque rupture group were all significantly larger than those of the non-rupture group. CONCLUSIONS: The 64-slice MDCT can identify differences in lesion morphologies between ruptured plaques and non-ruptured plaques. From our results, the 64-slice MDCT might provide a useful tool for the non-invasive detection of plaque rupture.
Atsushi Tanaka; Kenei Shimada; Ken Yoshida; Satoshi Jissyo; Hidemasa Tanaka; Makoto Sakamoto; Kunio Matsuba; Toshio Imanishi; Takashi Akasaka; Junichi Yoshikawa
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  72     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-25     Completed Date:  2008-10-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1276-81     Citation Subset:  IM    
Wakayama Medical University, Department of CArdiovascular Medicine, Wakayama, Japan.
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MeSH Terms
Angina Pectoris / etiology*,  radiography,  ultrasonography
Coronary Angiography / methods*
Coronary Stenosis / complications,  radiography*,  ultrasonography*
Middle Aged
Predictive Value of Tests
Radiographic Image Interpretation, Computer-Assisted
Tomography, X-Ray Computed*
Ultrasonography, Interventional*

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