| Non-invasive assessment of plaque rupture by 64-slice multidetector computed tomography--comparison with intravascular ultrasound. | |
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MedLine Citation:
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PMID: 18654013 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Plaque rupture and secondary thrombus formation play key roles in the onset of acute coronary syndrome (ACS). Multidetector computed tomography (MDCT) allows the non-invasive assessment of coronary artery stenosis and plaque properties. In this study, we investigated whether 64-slice MDCT could non-invasively detect a plaque rupture in patients with de novo angina. METHODS AND RESULTS: The study population comprised 67 patients with de novo angina. All patients underwent contrast-enhanced 64-slice MDCT and intravascular ultrasound (IVUS). Patients were divided into a plaque rupture group (n=27) and a non-rupture group (n=40) based on the IVUS. The 64-slice MDCT revealed that the prevalence of an ulcer-like enhancement space (37% vs 5%, p<0.01), a ring-like sign (41% vs 18%, p=0.04), in the plaque rupture group was higher than those in the non-rupture group. Maximum plaque thickness (2.1+/-0.9 mm vs 1.6+/-1.0 mm, p=0.04), outer vessel area (17.6+/-4.9 mm2 vs 13.4+/-5.0 mm2, p<0.01), percentage plaque area (82.3+/-9.1% vs 73.4+/-15.7%, p=0.01), and remodeling index (1.11+/-0.18 vs 1.01+/-0.15, p=0.04) of the plaque rupture group were all significantly larger than those of the non-rupture group. CONCLUSIONS: The 64-slice MDCT can identify differences in lesion morphologies between ruptured plaques and non-ruptured plaques. From our results, the 64-slice MDCT might provide a useful tool for the non-invasive detection of plaque rupture. |
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Authors:
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Atsushi Tanaka; Kenei Shimada; Ken Yoshida; Satoshi Jissyo; Hidemasa Tanaka; Makoto Sakamoto; Kunio Matsuba; Toshio Imanishi; Takashi Akasaka; Junichi Yoshikawa |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 72 ISSN: 1346-9843 ISO Abbreviation: Circ. J. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-25 Completed Date: 2008-10-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 1276-81 Citation Subset: IM |
Affiliation:
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Wakayama Medical University, Department of CArdiovascular Medicine, Wakayama, Japan. a-tanaka@wakayama-med.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angina Pectoris / etiology*, radiography, ultrasonography Coronary Angiography / methods* Coronary Stenosis / complications, radiography*, ultrasonography* Female Humans Male Middle Aged Predictive Value of Tests Radiographic Image Interpretation, Computer-Assisted Rupture Tomography, X-Ray Computed* Ultrasonography, Interventional* |
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