Document Detail

Non-invasive assessment of myocardial contractility from force-frequency relationship in patients with implanted pacemakers: first results.
MedLine Citation:
PMID:  20382968     Owner:  NLM     Status:  MEDLINE    
AIMS: In the normal heart, myocardial contractility is augmented at elevated heart rates. This effect is known as force-frequency relationship (FFR). The FFR is altered in failing hearts and may be used to detect myocardial function impairment. Force-frequency relationship measurements usually require invasive techniques and have therefore rarely been used in clinical practice. We studied the feasibility of FFR determination by implanted pacemakers as a non-invasive method in pacemaker patients. METHODS AND RESULTS: During follow-up visits in 30 patients with implanted pacemakers and normal heart function, the intracardiac impedance (IZ) was recorded by the pacemaker during incremental pacing at 80, 100, and 120 bpm. The time interval between the ventricular pacing pulse and IZmax (tIZm) and the maximum acceleration of the IZ change during myocardial contraction (IZacc: d2Z/dt2 max) were determined. Isovolumetric acceleration (IVA) was measured in parallel by tissue Doppler echocardiography at the right free wall, the left free wall, and the septum. With increasing pacing rates, the time interval tIZm shortened significantly and maximum acceleration IZacc increased significantly, consistent with the FFR. The best correlation was achieved between IZacc and IVA septal. CONCLUSION: Permanent pacemakers offering intracardiac IZ measurements can be used for monitoring FFR changes and, possibly, for low-effort first-line monitoring of myocardial disease.
Hansjuergen Bondke; Adrian-Constantin Borges; Sven Petersen; Thomas Walde; Gert Baumann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-10
Journal Detail:
Title:  Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology     Volume:  12     ISSN:  1532-2092     ISO Abbreviation:  Europace     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-22     Completed Date:  2010-10-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883649     Medline TA:  Europace     Country:  England    
Other Details:
Languages:  eng     Pagination:  968-71     Citation Subset:  IM    
Department of Internal Medicine Cardiology and Angiology, Charité Universitätsmedizin Berlin, CC13, 10098 Berlin, Germany.
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MeSH Terms
Diagnosis, Computer-Assisted / methods*
Heart Function Tests / methods*
Myocardial Contraction*
Pacemaker, Artificial*
Pilot Projects
Reproducibility of Results
Sensitivity and Specificity
Ventricular Dysfunction, Left / diagnosis,  physiopathology*,  prevention & control

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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