Document Detail


Non-invasive assessment of hepatic fat accumulation in chronic hepatitis C by 1H magnetic resonance spectroscopy.
MedLine Citation:
PMID:  19406596     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Liver biopsy is the standard method for diagnosis of hepatic steatosis, but is invasive and carries some risk of morbidity.
AIMS AND METHODS: Quantification of hepatocellular lipid content (HCL) with non-invasive single voxel (1)H magnetic resonance spectroscopy (MRS) at 3T was compared with histological grading and biochemical analysis of liver biopsies in 29 patients with chronic hepatitis C. Body mass index, indices of insulin resistance (homeostasis model assessment index, HOMA-IR), serum lipids and serum liver transaminases were also quantified.
RESULTS: HCL as assessed by (1)H MRS linearly correlated (r=0.70, p<0.001) with histological evaluation of liver biopsies and was in agreement with histological steatosis staging in 65% of the patients. Biochemically assessed hepatic triglyceride contents correlated with HCL measured with (1)H MRS (r=0.63, p<0.03) and allowed discriminating between none or mild steatosis versus moderate or severe steatosis. Patients infected with hepatitis C virus genotype 3 had a higher prevalence of steatosis (62%) which was not explained by differences in body mass or whole body insulin resistance. When these patients were excluded from correlation analysis, hepatic fat accumulation positively correlated with insulin resistance in the remaining hepatitis C patients (HCL vs. HOMA-IR, r=0.559, p<0.020, n=17).
CONCLUSION: Localized (1)H MRS is a valid and useful method for quantification of HCL content in patients with chronic hepatitis C and can be easily applied to non-invasively monitoring of steatosis during repeated follow-up measurements in a clinical setting.
Authors:
Martin Krssák; Harald Hofer; Fritz Wrba; Martin Meyerspeer; Attila Brehm; Alfred Lohninger; Petra Steindl-Munda; Ewald Moser; Peter Ferenci; Michael Roden
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-04-29
Journal Detail:
Title:  European journal of radiology     Volume:  74     ISSN:  1872-7727     ISO Abbreviation:  Eur J Radiol     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-08-05     Completed Date:  2011-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106411     Medline TA:  Eur J Radiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  e60-6     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Department of Internal Medicine III, Division of Endocrinology and Metabolism, Medical University of Vienna, Austria.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / metabolism*
Adult
Fatty Liver / diagnosis*,  etiology,  metabolism*
Female
Hepatitis C, Chronic / complications,  diagnosis*,  metabolism*
Humans
Lipids / analysis*
Magnetic Resonance Spectroscopy / methods*
Male
Protons / diagnostic use
Reproducibility of Results
Sensitivity and Specificity
Chemical
Reg. No./Substance:
0/Lipids; 0/Protons

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