| Non-invasive assessment of endothelial function - relation between vasodilatory responses in skin microcirculation and brachial artery. | |
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MedLine Citation:
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PMID: 15522039 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare different non-invasive methods for determination of human endothelial function in peripheral circulation. DESIGN: Observational, cross-sectional study in 39 healthy subjects (21 females, age 17-56 years). SETTING: Vascular research laboratory at university hospital. METHODS: Laser Doppler (LD) flowmetry was used to compare skin microvascular perfusion changes during postocclusive reactive hyperaemia with those induced by iontophoretic administration of acetylcholine (ACh), an endothelial-dependent vasodilator. LD measurements were compared with ultrasonographic measurements of postocclusive flow-mediated dilatation (FMD) in the brachial artery (n = 21). RESULTS: Local ACh induced a larger and more sustained skin perfusion increase than reactive hyperaemia after 4 min of regional arterial occlusion (P<0.001). A significant correlation was found between the magnitude of ACh-induced vasodilatation and peak reactive hyperaemia, both in absolute (r = 0.62, P<0.001) and relative terms (r = 0.58, P<0.001). A correlation was also found between brachial artery FMD and the magnitude of ACh-induced skin perfusion increase (r = 0.43, P<0.05) but not between FMD and reactive hyperaemia. CONCLUSION: Endothelial function, an early marker of cardiovascular risk, can be non-invasively assessed and graded by LD and FMD-measurements and despite inherent differences, both methods do correlate. |
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Authors:
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Jimmy Hansell; Loghman Henareh; Stefan Agewall; Mikael Norman |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Validation Studies |
Journal Detail:
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Title: Clinical physiology and functional imaging Volume: 24 ISSN: 1475-0961 ISO Abbreviation: Clin Physiol Funct Imaging Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-11-03 Completed Date: 2005-02-15 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101137604 Medline TA: Clin Physiol Funct Imaging Country: England |
Other Details:
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Languages: eng Pagination: 317-22 Citation Subset: IM |
Affiliation:
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Department of Women and Child Health, Huddinge University Hospital, Stockholm, Sweden. hansell@swipnet.se |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Brachial Artery / physiology*, ultrasonography* Endothelium, Vascular / physiology*, ultrasonography* Female Humans Laser-Doppler Flowmetry / methods* Male Microcirculation / physiology, ultrasonography Middle Aged Reproducibility of Results Sensitivity and Specificity Skin / blood supply*, ultrasonography* Statistics as Topic Vasodilation / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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