Document Detail


Non invasive analysis of hemodynamic changes in dogs with acute pancreatitis.
MedLine Citation:
PMID:  1724993     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To elucidate the hemodynamic changes in the course of acute pancreatitis in dogs, various parameters were monitored non-invasively and real-timely by the ultrasonic flow probes which had been placed in advance. The dogs were divided into two groups, i.e., control group (CG) and infusion group (IG). In the infusion group, lactated Ringer solution was infused intravenously for 12 hours in order to maintain LAP or CVP at the mean +/- 1 mmHg of its control value before inducing pancreatitis. In the control group, lactated Ringer solution was not infused. Cardiac output (CO) and LV dp/dt abruptly decreased in a few hours and remained low levels in a control group (CG), but not in an infusion group (IG). It shows that the decreased CO was caused by a decrease in preload but not by a depression of contractility. Gastroduodenal arterial flow (GDAF) and GDAF/CO decreased in a few hours and kept low level in CG, but not in IG. Therefore, a decrease in GDAF is mainly caused by an increase in vascular resistance due to an increase in Hematocrit. Superior pancreatico-duodenal venous flow (SPDVF) and SPDVF/CO decreased immediately in both groups, revealing that there is severely depressive outflow from pancreas because of hemorrhage and destruction of pancreatic parenchyma immediately after the onset of pancreatitis. In CG, Total hepatic flow (THF) and Portal vein flow (PVF) gradually decreased in a few hours and kept low levels, but Common hepatic arterial flow (CHAF) did not decrease. This suggests that decrease of THF is due to decrease of PVF. THF/CO increased in CG. PVF/CO decreased in CG, while CHAF/CO increased in both groups. The increased CHAF compensated for the decreased PVF, which may play an important role in protecting the liver.
Authors:
Y Tsukamoto; H Ohyanagi; H Hosomi; Y Saitoh
Related Documents :
22523353 - Acetazolamide and chronic hypoxia: effects on hemorheology and pulmonary hemodynamics.
23574003 - Hidden acidosis: an explanation of acid-base and lactate changes occurring in umbilical...
22283413 - Continuous flow synthesis. a pharma perspective.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Kobe journal of medical sciences     Volume:  37     ISSN:  0023-2513     ISO Abbreviation:  Kobe J Med Sci     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1992-04-28     Completed Date:  1992-04-28     Revised Date:  2008-04-08    
Medline Journal Info:
Nlm Unique ID:  0413531     Medline TA:  Kobe J Med Sci     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  189-208     Citation Subset:  IM    
Affiliation:
Department of Surgery, Kobe University School of Medicine, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acute Disease
Amylases / blood
Animals
Blood Flow Velocity
Cardiac Output
Dogs
Duodenum / blood supply
Female
Hemodynamics*
Liver Circulation
Male
Pancreas / enzymology,  pathology
Pancreatitis / pathology,  physiopathology*,  ultrasonography
Portal Vein / physiopathology
Stomach / blood supply
Trypsin / blood
Chemical
Reg. No./Substance:
EC 3.2.1.-/Amylases; EC 3.4.21.4/Trypsin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  NIK-247 blocks voltage-dependent ionic currents in crayfish axon.
Next Document:  Possible collaboration between c-fos and c-myc proto-oncogene products in in vivo lymphomagenesis.