Document Detail

Non invasive analysis of hemodynamic changes in dogs with acute pancreatitis.
MedLine Citation:
PMID:  1724993     Owner:  NLM     Status:  MEDLINE    
To elucidate the hemodynamic changes in the course of acute pancreatitis in dogs, various parameters were monitored non-invasively and real-timely by the ultrasonic flow probes which had been placed in advance. The dogs were divided into two groups, i.e., control group (CG) and infusion group (IG). In the infusion group, lactated Ringer solution was infused intravenously for 12 hours in order to maintain LAP or CVP at the mean +/- 1 mmHg of its control value before inducing pancreatitis. In the control group, lactated Ringer solution was not infused. Cardiac output (CO) and LV dp/dt abruptly decreased in a few hours and remained low levels in a control group (CG), but not in an infusion group (IG). It shows that the decreased CO was caused by a decrease in preload but not by a depression of contractility. Gastroduodenal arterial flow (GDAF) and GDAF/CO decreased in a few hours and kept low level in CG, but not in IG. Therefore, a decrease in GDAF is mainly caused by an increase in vascular resistance due to an increase in Hematocrit. Superior pancreatico-duodenal venous flow (SPDVF) and SPDVF/CO decreased immediately in both groups, revealing that there is severely depressive outflow from pancreas because of hemorrhage and destruction of pancreatic parenchyma immediately after the onset of pancreatitis. In CG, Total hepatic flow (THF) and Portal vein flow (PVF) gradually decreased in a few hours and kept low levels, but Common hepatic arterial flow (CHAF) did not decrease. This suggests that decrease of THF is due to decrease of PVF. THF/CO increased in CG. PVF/CO decreased in CG, while CHAF/CO increased in both groups. The increased CHAF compensated for the decreased PVF, which may play an important role in protecting the liver.
Y Tsukamoto; H Ohyanagi; H Hosomi; Y Saitoh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Kobe journal of medical sciences     Volume:  37     ISSN:  0023-2513     ISO Abbreviation:  Kobe J Med Sci     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1992-04-28     Completed Date:  1992-04-28     Revised Date:  2008-04-08    
Medline Journal Info:
Nlm Unique ID:  0413531     Medline TA:  Kobe J Med Sci     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  189-208     Citation Subset:  IM    
Department of Surgery, Kobe University School of Medicine, Japan.
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MeSH Terms
Acute Disease
Amylases / blood
Blood Flow Velocity
Cardiac Output
Duodenum / blood supply
Liver Circulation
Pancreas / enzymology,  pathology
Pancreatitis / pathology,  physiopathology*,  ultrasonography
Portal Vein / physiopathology
Stomach / blood supply
Trypsin / blood
Reg. No./Substance:
EC 3.2.1.-/Amylases; EC

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