Document Detail


Non-invasive accurate measurement of arterial PCO(2) in a pediatric animal model.
MedLine Citation:
PMID:  23100168     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The PCO(2) in arterial blood (PaCO(2)) is a good parameter for monitoring ventilation and acid-base changes in ventilated patients, but its measurement is invasive and difficult to obtain in small children. Attempts have been made to use the partial pressure of CO(2) in end-tidal gas (PETCO(2)), as a noninvasive surrogate for PaCO(2). Studies have revealed that, unfortunately, the differences between PETCO(2) and PaCO(2) are too variable to be clinically useful. We hypothesized that end-inspiratory rebreathing, previously shown to equalize PETCO(2) and PaCO(2) in spontaneously breathing humans, would also be effective with positive pressure ventilation. Eight newborn Yorkshire pigs were mechanically ventilated via a partial rebreathing circuit to implement end-inspiratory rebreathing. Arterial blood was sampled and tested for PaCO(2). A variety of alveolar ventilations resulting in different combinations of end-tidal PCO(2) (30-50 mmHg) and PO(2) (35-500 mmHg) were tested for differences between PETCO(2) and PaCO(2) (PET-aCO(2)). The PET-aCO(2) of all samples was (mean ± 1.96 SD) 0.4 ± 2.7 mmHg. Our study demonstrates that, in ventilated juvenile animals, end-inspiratory rebreathing maintains PET-aCO(2) to what would be a clinically useful range. If verified clinically, this approach could open the way for non-invasive monitoring of arterial PCO(2) in critically ill patients.
Authors:
Jorn Fierstra; Jeff D Winter; Matthew Machina; Jelena Lukovic; James Duffin; Andrea Kassner; Joseph A Fisher
Related Documents :
15321118 - Oxford positioning technique improves haemodynamic stability and predictability of bloc...
9861128 - Haemodynamic and electroencephalographic response to insertion of a cuffed oropharyngea...
2919758 - A randomized comparison between midazolam and thiopental for elective cesarean section ...
15220768 - Evidence that intravenous vasopressors can affect rostral spread of spinal anesthesia i...
15687838 - Molecular and cellular mechanisms in vascular injury in hypertension: role of angiotens...
2033008 - Erythrocyte deformability and lung segmental vascular resistance: effect of hematocrit.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-26
Journal Detail:
Title:  Journal of clinical monitoring and computing     Volume:  -     ISSN:  1573-2614     ISO Abbreviation:  J Clin Monit Comput     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9806357     Medline TA:  J Clin Monit Comput     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Division of Neurosurgery, University Health Network, Toronto, ON, Canada, jornfierstra@gmail.com.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Pharmacokinetics of a Fixed-Dose Combination of Mitiglinide and Metformin versus Concurrent Administ...
Next Document:  Self-assembled GaN quantum wires on GaN/AlN nanowire templates.