Document Detail


Non-invasive ICG-clearance: a useful tool for the management of hepatic artery thrombosis following liver transplantation.
MedLine Citation:
PMID:  20412097     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Levesque E, Hoti E, Azoulay D, Adam R, Samuel D, Castaing D, Saliba F. Non-invasive ICG-clearance: a useful tool for the management of hepatic artery thrombosis following liver transplantation. Clin Transplant 2011: 25: 297-301. © 2010 John Wiley & Sons A/S. Abstract:  Background:  The clinical presentation of hepatic artery thrombosis (HAT) post-liver transplantation (LT) varies considerably. Doppler ultrasonography (Doppler US) is the first line investigation, with a diagnostic sensitivity for HAT as high as 92%. Because indocyanine green (ICG) elimination from the blood depends among other factors on the hepatic blood flow, we hypothesized that plasma disappearance rate of indocyanine green (PDR-ICG) can be influenced by the flow in the hepatic artery. Thus, we evaluated the role of PDR-ICG measurement in HAT diagnosis in post-LT patients. Patients and methods:  Fourteen liver transplant patients with no visible flow in the hepatic artery (Doppler US) were identified. Of the 14, seven patients had HAT confirmed by CT-angiography. The PDR-ICG measurement, an investigation routinely used in our center, was performed in all 14 patients. Results:  The PDR-ICG in patients with HAT was significantly lower than in patients without HAT (5.8 ± 4.3 vs. 23.8 ± 7.4%/min, p = 0.0009). In patients with HAT, after the revascularization, the PDR-ICG value increased (5.8 ± 4.3 vs. 15.6 ± 3.5%/min, p = 0.006). Conclusion:  The ICG elimination may be an adjunct diagnostic tool in the management of patients with suspected HAT following LT.
Authors:
E Levesque; E Hoti; D Azoulay; R Adam; D Samuel; D Castaing; F Saliba
Related Documents :
9356867 - Auxiliary heterotopic partial liver transplantation in pigs with acute ischemic liver f...
12709077 - Emergency living related liver transplantation for fulminant reactivation of hepatitis ...
19104697 - Costs and efficacy of "on demand" low-dose immunoprophylaxis in hbv transplanted patien...
11291257 - Treatment strategies for recurrent hepatitis c after liver transplantation.
15153477 - Requirement for donor and recipient cd40 expression in cardiac allograft rejection: ind...
21241247 - Adverse effects of tacrolimus in renal transplant patients from living donors.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical transplantation     Volume:  25     ISSN:  1399-0012     ISO Abbreviation:  Clin Transplant     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-04-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710240     Medline TA:  Clin Transplant     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  297-301     Citation Subset:  IM    
Copyright Information:
© 2010 John Wiley & Sons A/S.
Affiliation:
AP-HP Hôpital Paul Brousse, Centre Hépato-Biliaire Univ Paris-Sud, UMR-S 785 Inserm, Unité 785, Villejuif, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Contrast-enhanced ultrasound vs multidetector-computed tomography for detecting liver metastases in ...
Next Document:  Monitoring of minimal residual disease by quantitative WT1 gene expression following reduced intensi...