| Non-invasive ICG-clearance: a useful tool for the management of hepatic artery thrombosis following liver transplantation. | |
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MedLine Citation:
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PMID: 20412097 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Levesque E, Hoti E, Azoulay D, Adam R, Samuel D, Castaing D, Saliba F. Non-invasive ICG-clearance: a useful tool for the management of hepatic artery thrombosis following liver transplantation. Clin Transplant 2011: 25: 297-301. © 2010 John Wiley & Sons A/S. Abstract: Background: The clinical presentation of hepatic artery thrombosis (HAT) post-liver transplantation (LT) varies considerably. Doppler ultrasonography (Doppler US) is the first line investigation, with a diagnostic sensitivity for HAT as high as 92%. Because indocyanine green (ICG) elimination from the blood depends among other factors on the hepatic blood flow, we hypothesized that plasma disappearance rate of indocyanine green (PDR-ICG) can be influenced by the flow in the hepatic artery. Thus, we evaluated the role of PDR-ICG measurement in HAT diagnosis in post-LT patients. Patients and methods: Fourteen liver transplant patients with no visible flow in the hepatic artery (Doppler US) were identified. Of the 14, seven patients had HAT confirmed by CT-angiography. The PDR-ICG measurement, an investigation routinely used in our center, was performed in all 14 patients. Results: The PDR-ICG in patients with HAT was significantly lower than in patients without HAT (5.8 ± 4.3 vs. 23.8 ± 7.4%/min, p = 0.0009). In patients with HAT, after the revascularization, the PDR-ICG value increased (5.8 ± 4.3 vs. 15.6 ± 3.5%/min, p = 0.006). Conclusion: The ICG elimination may be an adjunct diagnostic tool in the management of patients with suspected HAT following LT. |
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Authors:
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E Levesque; E Hoti; D Azoulay; R Adam; D Samuel; D Castaing; F Saliba |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical transplantation Volume: 25 ISSN: 1399-0012 ISO Abbreviation: Clin Transplant Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-04-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710240 Medline TA: Clin Transplant Country: Denmark |
Other Details:
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Languages: eng Pagination: 297-301 Citation Subset: IM |
Copyright Information:
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© 2010 John Wiley & Sons A/S. |
Affiliation:
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AP-HP Hôpital Paul Brousse, Centre Hépato-Biliaire Univ Paris-Sud, UMR-S 785 Inserm, Unité 785, Villejuif, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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