Document Detail


Non-interventional study to investigate the efficacy and safety of Tegaderm™ Matrix in the treatment of patients with therapy-refractory chronic wounds.
MedLine Citation:
PMID:  21999577     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background: Despite a variety of therapeutic approaches, many patients with chronic wounds remain refractory to treatment. Products such as Tegaderm™ Matrix were developed especially for such patients to alter the wound environment and reactivate the stagnant wound healing process. Patients and Methods: In this prospective post-authorization observational product study, a total of 314 patients with therapy-refractory chronic wounds of various origins were evaluated. Beside to the wound area reduction and healing rate, the occurrence of adverse events was documented. Results: On average the wounds were 10 months old. The average wound size was 17.3 cm(2) (median 6.3 cm(2) ) at the initial visit. In the course of treatment the wound size decreased to 13.0 cm(2) (median 3.5 cm(2) ) and was finally reduced to 9.3 cm(2) (median 0.9 cm(2) ) at end of the study. Taking the criteria of the European Wound Management Association for improving the quality of clinical studies into consideration, a wound size reduction of at least 50 % is the parameter for successful treatment of chronic wounds. This study demonstrated a wound size reduction of at least 50 % for 72.9 % of the patients with therapy-refractory chronic wounds when treated with Tegaderm™ Matrix. The safety profile was evaluated; only 4.7 % of the patients experienced a treatment-related adverse event such as a burning sensation. Conclusions: The results of the study demonstrate that Tegaderm™ Matrix along with treatment of underlying causes is a well tolerated wound dressing promoting wound size reduction up to healing for the majority of patients with previously therapy-refractory chronic wounds.
Authors:
Maren Weindorf; Andreas Körber; Joachim Klode; Joachim Dissemond
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-17
Journal Detail:
Title:  Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG     Volume:  -     ISSN:  1610-0387     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101164708     Medline TA:  J Dtsch Dermatol Ges     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© The Authors • Journal compilation © Blackwell Verlag GmbH, Berlin.
Affiliation:
Department of Dermatology, Venereology and Allergy, University Clinic of Essen, Germany.
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