| The Non-impact of Gestational Age on Neuro-developmental Outcome for Ventilated Survivors Born at 23 - 28 Weeks Gestation. | |
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MedLine Citation:
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PMID: 22277021 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aim: It has long been known that survival of preterm infants strongly depends upon birth weight and gestational age. This study addresses a different question - whether gestational maturity improves neuro-developmental outcomes for ventilated infants born at 23-28 weeks who survive to NICU discharge. Methods: We performed a prospective cohort study of 199 ventilated infants born between 23-28 weeks gestation. Neuro-developmental impairment was determined using the Bayley Scales of Infant Development - II at 24 months. Results: As expected, when considered as a ratio of all births, both survival and survival without neuro-developmental impairment were strongly dependent on gestational age. However, the percentage of surviving infants who displayed neuro-developmental impairment did not vary with gestational age for any level of neuro-developmental impairment (MDI or PDI <50, <60, <70). Moreover, since a higher percentage of ventilated infants survived to NICU discharge at higher gestational ages, but the percentage of neuro-developmental impairment in NICU survivors was unaffected by gestational age, the percentage of all ventilated births who survived with neuro-developmental impairment rose - not fell - with increasing gestation age, Conclusion: For physicians, parents, and policy-makers whose primary concern is the presence of neuro-developmental impairment in infants who survive the NICU, reliance on gestational age appears to be misplaced. © 2012 The Author(s)/Acta PÃdiatrica © 2012 Foundation Acta PÃdiatrica. |
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Authors:
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Bree Andrews; Joanne Lagatta; Alison Chu; Susan Plesha-Troyke; Michael Schreiber; John Lantos; William Meadow |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-25 |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: - ISSN: 1651-2227 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Author(s)/Acta PÃdiatrica © 2012 Foundation Acta PÃdiatrica. |
Affiliation:
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Department of Pediatrics, The University of Chicago, Chicago, IL Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI Department of Pediatrics, Children's Mercy Hospital, Kansas City, MO. |
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