Document Detail


The nonimpact of gestational age on neurodevelopmental outcome for ventilated survivors born at 23-28 weeks of gestation.
MedLine Citation:
PMID:  22277021     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: It has long been known that survival of preterm infants strongly depends upon birth weight and gestational age. This study addresses a different question - whether the gestational maturity improves neurodevelopmental outcomes for ventilated infants born at 23-28 weeks who survive to neonatal intensive care unit (NICU) discharge.
METHODS: We performed a prospective cohort study of 199 ventilated infants born between 23 and 28 weeks of gestation. Neurodevelopmental impairment was determined using the Bayley Scales of Infant Development-II at 24 months.
RESULTS: As expected, when considered as a ratio of all births, both survival and survival without neurodevelopmental impairment were strongly dependent on gestational age. However, the percentage of surviving infants who displayed neurodevelopmental impairment did not vary with gestational age for any level of neurodevelopmental impairment (MDI or PDI <50, <60, <70). Moreover, as a higher percentage of ventilated infants survived to NICU discharge at higher gestational ages, but the percentage of neurodevelopmental impairment in NICU survivors was unaffected by gestational age, the percentage of all ventilated births who survived with neurodevelopmental impairment rose - not fell - with increasing gestation age.
CONCLUSION: For physicians, parents and policy-makers whose primary concern is the presence of neurodevelopmental impairment in infants who survive the NICU, reliance on gestational age appears to be misplaced.
Authors:
Bree Andrews; Joanne Lagatta; Alison Chu; Susan Plesha-Troyke; Michael Schreiber; John Lantos; William Meadow
Publication Detail:
Type:  Journal Article     Date:  2012-02-13
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  101     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-04-26     Completed Date:  2012-08-02     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  574-8     Citation Subset:  IM    
Copyright Information:
© 2012 The Author(s)/Acta Paediatrica © 2012 Foundation Acta Paediatrica.
Affiliation:
Department of Pediatrics, The University of Chicago, IL 60637, USA.
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MeSH Terms
Descriptor/Qualifier:
Child Development*
Cohort Studies
Developmental Disabilities / epidemiology*
Female
Gestational Age*
Humans
Infant, Newborn
Infant, Premature / growth & development*
Male
Nervous System / growth & development*
Prospective Studies
Respiration, Artificial*
Grant Support
ID/Acronym/Agency:
UL1 TR000055/TR/NCATS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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