Document Detail

Non-iatrogenic pathology of the preterm infant.
MedLine Citation:
PMID:  15251145     Owner:  NLM     Status:  MEDLINE    
Non-iatrogenic anatomical findings at autopsy provide insight into preterm infant physiology. The different patterns of lipid accumulation in the adrenal may correspond to long-term differences in stress response. Cardiac papillary muscle infarction occurs with asphyxia or shock and can explain myocardial dysfunction. Underdevelopment of preterm kidneys may correlate with susceptibility to renal disease and hypertension in adult life. Immaturity of the lung or immature responses to inflammation, rather than high oxygen concentrations or high ventilation pressures, may underlie chronic lung disease in premature infants. Hepatic extramedullary haematopoiesis is normal but, if excessive or abnormally persistent, can be an indicator of fetal disease. Hypertrophic somatostatin islet cells found with intra-uterine growth retardation may correlate with low serum insulin. Thymic involution may mark the degree of stress. Small thyroglobulin stores may limit the premature neonate's initiation of thermogenesis.
Robert W Bendon; Susan Coventry
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in neonatology : SN     Volume:  9     ISSN:  1084-2756     ISO Abbreviation:  Semin Neonatol     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-14     Completed Date:  2004-10-26     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9606001     Medline TA:  Semin Neonatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  281-7     Citation Subset:  IM    
Copyright Information:
Copyright 2004 Elsevier Ltd.
Department of Pathology, Kosair Children's Hospital, P.O. Box 35070, Louisville, KY 40232-5070, USA.
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MeSH Terms
Adrenal Gland Diseases / congenital,  pathology
Bronchopulmonary Dysplasia / pathology
Heart Diseases / congenital,  pathology
Infant, Newborn
Infant, Premature, Diseases / pathology*
Islets of Langerhans / pathology
Kidney Diseases / congenital,  pathology
Liver Diseases / congenital,  pathology
Lung Diseases / congenital,  pathology
Thymus Gland / pathology
Thyroid Diseases / congenital,  pathology

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