| Non-high-density lipoprotein and very-low-density lipoprotein cholesterol and their risk predictive values in coronary heart disease. | |
| | |
MedLine Citation:
|
PMID: 17134630 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To determine if non-high-density lipoprotein (HDL) cholesterol is a more useful predictor of coronary heart disease (CHD) risk than low-density lipoprotein (LDL) cholesterol and if very-low-density lipoprotein (VLDL) cholesterol is an independent predictor of CHD risk, data from the Framingham Heart Study (2,693 men, 3,101 women) were used for this analysis. All subjects were aged > or =30 years and free of CHD at baseline, and incident CHD was the end point (618 men, 372 women). Cox proportional-hazards models were used to assess the risk for CHD (relative risks and 95% confidence intervals) on the basis of the joint distribution of LDL cholesterol and non-HDL cholesterol (in milligrams per deciliter), as well as LDL cholesterol, non-HDL cholesterol, and VLDL cholesterol as continuous variables. After multivariate adjustment, within non-HDL cholesterol level, no association was found between LDL cholesterol and the risk for CHD, whereas within LDL cholesterol levels, a strong positive and graded association between non-HDL cholesterol and risk for CHD was observed. When the analysis was repeated within triglyceride levels (<200 vs > or =200 mg/dl), the risk pattern did not change significantly. Also, VLDL cholesterol was found to be a significant predictor of CHD risk after adjusting for LDL cholesterol at triglyceride levels of > or =200 or <200 mg/dl. In conclusion, these results suggest that non-HDL cholesterol level is a stronger predictor of CHD risk than LDL cholesterol; that is, VLDL cholesterol may play a critical role in the development of CHD. |
| | |
Authors:
|
Jian Liu; Christopher T Sempos; Richard P Donahue; Joan Dorn; Maurizio Trevisan; Scott M Grundy |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2006-09-29 |
Journal Detail:
|
Title: The American journal of cardiology Volume: 98 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2006 Nov |
Date Detail:
|
Created Date: 2006-11-30 Completed Date: 2007-01-19 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
|
Languages: eng Pagination: 1363-8 Citation Subset: AIM; IM |
Affiliation:
|
Brock University, St. Catharines, Ontario, Canada. jliu@brocku.ca |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Cholesterol, LDL / blood* Cholesterol, VLDL / blood* Coronary Disease / blood*, epidemiology Female Humans Lipoproteins, HDL / blood Male Middle Aged Predictive Value of Tests Proportional Hazards Models Risk Factors |
| Chemical | |
Reg. No./Substance:
|
0/Cholesterol, LDL; 0/Cholesterol, VLDL; 0/Lipoproteins, HDL |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Value of prolonged QRS duration as a predictor of low cardiac output syndrome in patients with impai...
Next Document: Comparison of apolipoprotein-B/apolipoprotein-AI in subjects with versus without the metabolic syndr...