Document Detail


Non-heparin glycosaminoglycan-derived drugs: a biochemical and pharmacologic perspective.
MedLine Citation:
PMID:  1835134     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The developments in the area of glycosaminoglycan derived drugs can be summarized in the following: 1. Currently available glycosaminoglycan-derived drugs represent a first generation of clinically useful agents. At present these agents are not optimized and their basic and clinical pharmacology is poorly understood. 2. Most of these agents represent mixtures of different types of glycosaminoglycans. They can be purified to isolate their active components and perhaps many new drugs may be developed from the existing products. 3. Chemical derivatization and fractionation methods can be used to obtain more defined products. These products will be developed for specific clinical indications. 4. Each glycosaminoglycan derived product should be considered as an individual drug and should be developed separately. 5. Many semisynthetic and synthetic analogs of glycosaminoglycans will be introduced for various clinical indications.
Authors:
J M Walenga; D Hoppensteadt; J Fareed
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in thrombosis and hemostasis     Volume:  17 Suppl 2     ISSN:  0094-6176     ISO Abbreviation:  Semin. Thromb. Hemost.     Publication Date:  1991  
Date Detail:
Created Date:  1991-12-11     Completed Date:  1991-12-11     Revised Date:  2006-03-07    
Medline Journal Info:
Nlm Unique ID:  0431155     Medline TA:  Semin Thromb Hemost     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  137-42     Citation Subset:  IM    
Affiliation:
Department of Pathology, Loyola University Medical Center, Maywood, Illinois 60153.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antilipemic Agents / pharmacology*,  therapeutic use
Cattle / metabolism
Drug Design
Fibrinolytic Agents / pharmacology*,  therapeutic use
Glycosaminoglycans / isolation & purification,  pharmacology*,  therapeutic use
Molecular Structure
Molecular Weight
Plants / chemistry
Sheep / metabolism
Structure-Activity Relationship
Swine / metabolism
Chemical
Reg. No./Substance:
0/Antilipemic Agents; 0/Fibrinolytic Agents; 0/Glycosaminoglycans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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