| Non-heart-beating donors: a model of thoracic allograft injury. | |
| | |
MedLine Citation:
|
PMID: 8678686 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
4ACKGROUND. Non-heart-beating donors (NHBDs) have been proposed for the critical shortage of donors for cardiac and pulmonary transplantation. We determined the effects of prearrest hypoxia and postarrest warm ischemia on cardiac and pulmonary allografts procured from NHBDs undergoing hypoxic arrest. METHODS. Rabbit hearts and lungs were procured from separate donors and placed on isolated blood perfusion circuits. Controls were excised and perfused without ischemia. Heart from NHBDs underwent either prearrest hypoxic perfusion alone or consecutive periods of prearrest hypoxic perfusion and 20 minutes of postarrest warm ischemia. A third group of hearts underwent 30 minutes of warm, global ischemia alone. Two groups of pulmonary allografts were studied using similar hypoxic perfusion/20-minute ischemia and 30-minute ischemia donors. RESULTS. Prearrest hypoxic perfusion clearly causes significant dysfunction of cardiac allografts from NHBDs compared with nonischemic controls. Prearrest hypoxic perfusion combined with postarrest ischemia results in an additive degree of dysfunction more severe than a similar period of warm ischemia alone. Both groups of experimental lungs displayed function similar to that of nonischemic controls in terms of pulmonary hemodynamics, airway resistance, and oxygenation potential. CONCLUSIONS. We conclude that prearrest hypoxic perfusion significantly contributes to the dysfunction of NHBD cardiac allografts. Pulmonary allografts may be more amenable to procurement of NHBDs. |
| | |
Authors:
|
M C Mauney; J T Cope; O A Binns; R C King; K S Shockey; S A Buchanan; S W Wilson; J Cogbill; I L Kron; C G Tribble |
Related Documents
:
|
18192226 - Proteasome inhibition 1 h following ischemia protects grk2 and prevents malignant ventr... 10987346 - Differences between coronary hyperresponsiveness to ergonovine and vasospastic angina. 18316836 - Anaphylaxis-induced acute st-segment elevation myocardial ischemia treated with primary... 21930836 - Bright-blood t(2)-weighted mri has high diagnostic accuracy for myocardial hemorrhage i... 11828136 - Successful weaning from milrinone of a patient with severe congestive heart failure usi... 1861086 - Giant aneurysm of the coronary artery. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: The Annals of thoracic surgery Volume: 62 ISSN: 0003-4975 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 1996 Jul |
Date Detail:
|
Created Date: 1996-08-14 Completed Date: 1996-08-14 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 54-61; discussion 61-2 Citation Subset: AIM; IM |
Affiliation:
|
Department of Surgery, University of Virginia School of Medicine, Charlottesville, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Graft Survival / physiology* Heart Transplantation / methods*, physiology* Lung Transplantation / methods*, physiology* Myocardial Reperfusion / methods Myocardial Reperfusion Injury / etiology*, physiopathology Organ Preservation / methods* Rabbits Reperfusion / methods Reperfusion Injury / etiology*, physiopathology Time Factors Tissue Donors* Transplantation, Homologous |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Long-term results of operation for paravalvular abscess.
Next Document: Bilateral internal mammary artery grafting in women: a 21-year experience.