Document Detail


Non-heart-beating donors: a model of thoracic allograft injury.
MedLine Citation:
PMID:  8678686     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
4ACKGROUND. Non-heart-beating donors (NHBDs) have been proposed for the critical shortage of donors for cardiac and pulmonary transplantation. We determined the effects of prearrest hypoxia and postarrest warm ischemia on cardiac and pulmonary allografts procured from NHBDs undergoing hypoxic arrest. METHODS. Rabbit hearts and lungs were procured from separate donors and placed on isolated blood perfusion circuits. Controls were excised and perfused without ischemia. Heart from NHBDs underwent either prearrest hypoxic perfusion alone or consecutive periods of prearrest hypoxic perfusion and 20 minutes of postarrest warm ischemia. A third group of hearts underwent 30 minutes of warm, global ischemia alone. Two groups of pulmonary allografts were studied using similar hypoxic perfusion/20-minute ischemia and 30-minute ischemia donors. RESULTS. Prearrest hypoxic perfusion clearly causes significant dysfunction of cardiac allografts from NHBDs compared with nonischemic controls. Prearrest hypoxic perfusion combined with postarrest ischemia results in an additive degree of dysfunction more severe than a similar period of warm ischemia alone. Both groups of experimental lungs displayed function similar to that of nonischemic controls in terms of pulmonary hemodynamics, airway resistance, and oxygenation potential. CONCLUSIONS. We conclude that prearrest hypoxic perfusion significantly contributes to the dysfunction of NHBD cardiac allografts. Pulmonary allografts may be more amenable to procurement of NHBDs.
Authors:
M C Mauney; J T Cope; O A Binns; R C King; K S Shockey; S A Buchanan; S W Wilson; J Cogbill; I L Kron; C G Tribble
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  62     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-08-14     Completed Date:  1996-08-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  54-61; discussion 61-2     Citation Subset:  AIM; IM    
Affiliation:
Department of Surgery, University of Virginia School of Medicine, Charlottesville, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Graft Survival / physiology*
Heart Transplantation / methods*,  physiology*
Lung Transplantation / methods*,  physiology*
Myocardial Reperfusion / methods
Myocardial Reperfusion Injury / etiology*,  physiopathology
Organ Preservation / methods*
Rabbits
Reperfusion / methods
Reperfusion Injury / etiology*,  physiopathology
Time Factors
Tissue Donors*
Transplantation, Homologous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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