Document Detail

[Non-glucose carbohydrates in the parenteral nutrition of patients with systemic inflammatory response syndrome].
MedLine Citation:
PMID:  10364784     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare tolerance of two sources of isocaloric intake (fructose-glucose-xylitol mixture [FGX] versus glucose) in parenteral nutrition for patients with systemic inflammatory response syndrome (SIRS).
DESIGN: Open, prospective, cohort and randomized study.
SETTING: Intensive Care Unit.
SUBJECTS AND METHODS: Two groups of patients admitted in ICU: acute pneumonia with sepsis, and necro-hemorrhagic pancreatitis. Criteria of exclusion were: diabetes, previous hypertriglyceridemia, renal failure with serum creatinine > 3 mg/dL on admission in ICU, or hyperbilirrubinemia > 2.5 mg/dL. Parenteral nutrition (TPN), consisting of 1.4 g AA + Lipids 1.3 g + carbohydrates 4 g/kg/d, (either glucose or FGX at random) was administered. Basal levels and days 1st, 4th and 10th plasma glucose, triglycerides, cholesterol, uric acid were determined, and blood venous gases as well. Capillary glycemia was measured every 6 hours and insulin given if glucose levels rose above 180 mg/dL.
STATISTICS: Fisher's exact test; Student t-test; Mann-Whitney test. Data as mean and SD.
RESULTS AND CONCLUSIONS: During 48 months, 119 patients admitted in the ICU (72 with pneumonia and 47 with pancreatitis) were included. In pneumonia, tolerance was similar with both intakes; glycemia was kept at the same level in both, but the amount of insulin given was significantly more in those patients fed on glucose (p < 0.05). Nevertheless, resting blood glucose and triglyceride levels were higher in pancreatitic patients, and more insulin was required. Those on FGX had lower triglyceride plasma levels (p < 0.05) and less insulin was given throughout the study. Glycemia was kept lower though no statistical significance was reached (p < 0.1). No hyperuricemia nor lactic acidosis was found.
J López Martínez; M Sánchez Castilla; P de Juana Velasco; R Díaz Abad; J M Rodríguez Roldán; A García de Lorenzo y Mateos; F Del Nogal Sáez
Publication Detail:
Type:  Clinical Trial; English Abstract; Journal Article; Randomized Controlled Trial; Review    
Journal Detail:
Title:  Nutrición hospitalaria     Volume:  14     ISSN:  0212-1611     ISO Abbreviation:  Nutr Hosp     Publication Date:    1999 Mar-Apr
Date Detail:
Created Date:  1999-06-24     Completed Date:  1999-06-24     Revised Date:  2013-07-02    
Medline Journal Info:
Nlm Unique ID:  9100365     Medline TA:  Nutr Hosp     Country:  SPAIN    
Other Details:
Languages:  spa     Pagination:  71-80     Citation Subset:  IM    
Cuidados Intensivos, Hospital Severo Ochoa Leganés, Madrid, España.
Vernacular Title:
Hidratos de carbono no-glucosa en la nutrición parenteral de pacientes con síndrome de respuesta inflamatoria sistémica.
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MeSH Terms
Carbohydrates / administration & dosage*
Cohort Studies
Pancreatitis, Acute Necrotizing / therapy*
Parenteral Nutrition* / methods*
Pneumonia, Bacterial / therapy*
Prospective Studies
Systemic Inflammatory Response Syndrome / therapy*
Reg. No./Substance:

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