Document Detail

Non-functioning pituitary adenomas.
MedLine Citation:
PMID:  19945027     Owner:  NLM     Status:  MEDLINE    
Non-functioning pituitary tumours are mostly of gonadotroph cell origin and are devoid of humoral hypersecretory syndromes. They are usually large at the time of diagnosis, commonly presenting with headaches, visual field defects and hypopituitarism. Trans-sphenoidal surgery remains the treatment of choice for rapid decompression of neighbouring structures, often bringing to normalisation or improvement of visual and pituitary function. The management of patients with postoperative residual tumours is still a matter of debate and may include observation alone, the use of dopamine agonists or radiation therapy. There are no controlled or comparative studies of the available therapeutic options; therefore, recommendations are not evidence based. Patients need long-term follow-up for the detection and treatment of hypopituitarism, visual dysfunction and tumour growth that may develop over time.
Yona Greenman; Naftali Stern
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Best practice & research. Clinical endocrinology & metabolism     Volume:  23     ISSN:  1878-1594     ISO Abbreviation:  Best Pract. Res. Clin. Endocrinol. Metab.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-11-30     Completed Date:  2010-02-01     Revised Date:  2012-11-07    
Medline Journal Info:
Nlm Unique ID:  101120682     Medline TA:  Best Pract Res Clin Endocrinol Metab     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  625-38     Citation Subset:  IM    
Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv-Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, 6 Weizmann Street, Tel Aviv 64239, Israel.
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MeSH Terms
Adenoma / classification,  complications,  diagnosis*,  therapy
Gonadotropins, Pituitary / secretion
Hypopituitarism / diagnosis,  etiology
Neurosurgical Procedures / rehabilitation
Pituitary Neoplasms / classification,  complications,  diagnosis*,  therapy
Reg. No./Substance:
0/Gonadotropins, Pituitary

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