| Non-functioning, malignant pancreatic neuroendocrine tumour (PNET): a rare entity during pregnancy. | |
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MedLine Citation:
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PMID: 18512071 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Non-functioning pancreatic neuroendocrine tumours (PNET) are extremely rare tumours. To our knowledge, we are the first to report in the literature on two cases of PNET during pregnancy. PATIENTS: A 32- and a 35-year-old primigravida, both in their second trimester of pregnancy, were referred to our clinic because of a suspicious mass in the pancreas. Both patients had an uneventful medical history and their laboratory test results, including pancreatic hormones, were unremarkable. Both underwent surgical exploration and resection of the pancreatic tumour. One patient with a tumour in the pancreatic tail underwent a distal pancreatectomy and splenectomy, whereas in the other case a pylorus-preserving pancreaticoduodenectomy was performed due to a tumour in the pancreatic head. RESULTS: One of the patients delivered a healthy infant, which is now at the age of 6 years in excellent health. The other patient is now in her third trimester of pregnancy without any further complications. Histopathological analysis of both tumours showed a strong expression of chromogranin and synaptophysin, thus both were classified as well-differentiated, non-functioning neuroendocrine carcinomas. CONCLUSIONS: Although PNETs are extremely rare, this entity can be confirmed as another differential diagnosis for suspicious pancreatic mass during pregnancy. In specialized centres, these tumours can be removed without any harmful consequences to the foetus. |
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Authors:
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Carsten H Kamphues; Christoph Röcken; Peter Neuhaus; Ulf P Neumann |
Publication Detail:
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Type: Case Reports; Journal Article Date: 2008-05-30 |
Journal Detail:
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Title: Langenbeck's archives of surgery / Deutsche Gesellschaft für Chirurgie Volume: 394 ISSN: 1435-2451 ISO Abbreviation: Langenbecks Arch Surg Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-02-03 Completed Date: 2009-07-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9808285 Medline TA: Langenbecks Arch Surg Country: Germany |
Other Details:
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Languages: eng Pagination: 387-91 Citation Subset: IM |
Affiliation:
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Department of General, Visceral and Transplantation Surgery, Universitätsklinikum Charité, Campus Virchow-Klinikum, Humboldt-Universität, Berlin, Germany. carsten.kamphues@charite.de |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Follow-Up Studies Humans Infant, Newborn Magnetic Resonance Imaging Neuroectodermal Tumors, Primitive / diagnosis, pathology, surgery* Pancreas / pathology Pancreatectomy Pancreatic Neoplasms / diagnosis, pathology, surgery* Pancreaticoduodenectomy Pregnancy Pregnancy Complications, Neoplastic / diagnosis, pathology, surgery* Pregnancy Trimester, Second Splenectomy |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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